I used to have trouble sleeping, but now I'm on Klonopin, which also stopped my anxiety attacks. I don't know how related it is to the POTS, as depression/anxiety is hereditary in my family, but I've found that POTS affects basically everything. I don't have any snoring issues. Have you had a sleep study? It sounds like you might want to ask your pcp about one if you have this much difficulty. I definitely have worsening cognitive problems, ie "brain fog." I've found taking omega-3's and Cerefolin (which contains folic acid) help my concentration immensely, as does Mestinon. I don't have problems with excessive weight gain, but I do sometimes have nausea. I think it's because sometimes there's too much blood in the stomach or not enough blood, causing the stomach to digest when it shouldn't and not digest when it should, or something along those lines. I have blood pooling in my feet and hands, but I don't really have fluid retention in my legs. I more have difficulty retaining fluids at all. I hope this is helpful to you. I'm guessing many of those things are at least in some way POTS related. Meg