Dizzy Dame Posted January 31, 2006 Report Share Posted January 31, 2006 Hi all, Starting in early December, I began to have strange nighttime crashes that were different from my "normal" POTS crashes. I even posted on this awhile ago, and I know several of you remarked that you'd had similar events. A few days ago I had a mild episode here at Vanderbilt, and the symptoms were recorded, and a sample was gathered. My doctor, Dr. B, thinks these episodes could be attributed to a disorder called MCAD (Mast Cell Activation Disorder). There is very little literature on this subject, but Dr. B described it as a spontanious flood of methylhistamines in the stream, as though I'm having a severe allergic reaction. The result is profound tachycardia, hypertension, flushing (especially in the face), nausea, sweating, shaking, numbness in extremeties and shortness of breath/difficulty breathing (all of which I experience during my nighttime crashes). These symptoms may be triggered by excersize, standing, or in my case, nothing at all.The results of the test for methylhistamines won't come back for another week, but I thought I'd let you guys know since I know some of you have similar episodes. There is a link between POTS and Mast Cell Activation as outlined in the paper below (written in 2002).http://hyper.ahajournals.org/cgi/content/full/45/3/385 I hope this post helps point some of you with similar episodes in the right direction. I know the test can be done outside of Vanderbilt, so you wouldn't need to be hospitalized in order to get a diagnosis. Feel free to PM me if you have any other questions. Also, is there anyone here with MCAD? Cheers, Lauren Quote Link to comment Share on other sites More sharing options...
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