Increased Nitric Oxide In A Major Pots Subset

[ramakentesh]

One of the three large subgroups of POTS patients - Normal Flow POTS - catagorised by stomach/splanchnic blood pooling and excessive peripheral vasoconstriction on standing seems to be linked to increased endothelial nitric oxide synthesis through abherant nitrergic nerve activity:

http://ajpheart.physiology.org/content/early/2011/05/31/ajpheart.00171.2011.abstract

This would explain the effectiveness of Tumeric in this subgroup.

[toddm1960]

****..........I fit normal flow POTS to a tee, but when I tried tumeric I felt totaly rotten. I stopped taking it and within 24 hours was back to my normal crappy self Good article though ram, it's nice to see there is some research going on for POTS.

[ramakentesh]

In NET deficiency there can also be stomach pooling so its a little confusing. If you have postural hypertension your more likely low flow than normal flow, although as you no there are no concrete things in POTS.

[ramakentesh]

these results also confirmed in:

http://www.ajconline...0783-6/abstract

Crazy situation where nitric oxide defiency could cause some forms of POTS and too much nitric oxide could cause others...

it could explain the results of B12 injections in CFS patients (if they have POTS) as is it a potent nitric oxide scavenger. Tumeric, green tea and other scavengers would also be helpful potentially?? If on the other hand a person had bad responses to these types of scavengers or even more indicatively, bad reactions to competitive nitric oxide inhibators this might point the other direction (potentially).

Tumeric also made me feel terrible

[HopeSprings]

Can someone translate this into english for me? Seems interesting, if only I could understand what it all means.

[ramakentesh]

A large subset of POTS patients seem to have a primary problem where there is too much of a vasodilating molecule in their stomach circulation - causing excessive pooling specific to that location.

Another subset have too much angiotensin II which may be either effecting norepinephrine vasoconstriction, reuptake or neuronal / endothelial nitric oxide levels.

[juliegee]

Kind of makes me wonder if we can move between the sub-groups....

I could have sworn that I was a low-flow based upon the excessive amount of vasoconstriction that I have- severe reynauds. BUT I have benefitted from turmeric in the past- I've since developed a hypersensitivity to it - which seems to indicate normal-flow. Hmmmmm

So what am I low-flow or normal-flow?Could I be both? Can we move between the groups?

[ramakentesh]

From what they are saying at the moment, probably not. But who knows.

In normal flow there is extreme peripheral vasoconstriction but this is specific to orthostatic stress - in low flow its all the time (even supine).

[juliegee]

Aha, thanks Rama. I guess I must be "normal-flow" after all. Any stress (orthostatic or otherwise) will set off my Raynaud's, but I can usually get blood to my extremities when I lie down.

It's intermittently cooling off here in the South- we've dipped to freezing a few times and so far NO EXTREME vasospasms of my fingers and toes yet. Last winter I sported black fingers much of the time. The only thing I'm doing differently (as I can't tolerate any traditional treatment) is magnesium. It's relaxed my vasculature tremendously and even improved my tachy. My wonder mineral

[E246]

Hi Ramakantesh,

I couldn't open the link on your first message - could you post it again. Thanks.

Also if tumeric etc helps for normal flow is there something that helps increase NO for low flow - if this might be partially causing the problem?

Thanks

[toddm1960]

That's what gets me, I'm the same way I only over constrict when standing. HR & BP increase, and continue to increase as long as I stand, but feel awfull when taking tumeric. I also take 1,200mg of magnesium each morning. I fit everything in the normal flow description except for high NO.

[ramakentesh]

Blair Grubb says that in NET deficiency which he believes accounts for a subset of patients there are signs of both norepinephrine excess and not enough NE - either fluctuating from one to the other or at the same time.

[toddm1960]

This group will be known here after as the "inbtween flow" group...............