I have classic SFN sensory symptoms (burning feet) and POTS. I had a very positive skin biopsy, but a few months later a repeat skin biopsy and then another (long story) came back negative. There was no treatment in between and no change in symptoms. I was perplexed as SFN explained many of my symptoms so well. I then had a QSART which was very positive and positive again on repeat. I was diagnosed with SFN and they believe autonomic neuropathy is causing the POTS. It was explained to me (as Jensen said) that neuropathy can be patchy and therefore biopsy can miss it. I've heard before of other people having positive skin biopsy, negative QSART and vice versa, so I too think people should have both tests. It may not be SFN, but since you do have nerve pain and dysautonomia, I'd want to make sure. See if you can get the QSART. Another one I've heard of is a TST (thermoregulatory sweat test?), but I don't think it's widely available.