Hi Jacquie802, I haven't been on Zoloft before but I am currently on Paxil. When I started them I felt very "out of it", had headaches, was extra tired and lost my appetite so I think SSRIs can cause all sorts of symptoms until your body gets used to them. I think it took about 10 days before I stopped noticing these side effects. It is really hard at the time and you wonder if it's worth but it did get better. Paxil has really helped me. Try to hang in there! Hopefully if Zoloft agreed with you and helped you before they will again I started at a low dose to try and avoid start up effects-not sure if that helped though. I moved up twice in dosage later on and didn't experience any of those horrible effects again. I think once my system was used to them the change in dose wasn't so hard on my body. Hope you start to feel better soon!