Found the ROOT cause AUTOIMMUNE!

[andybonse]

Hey all,

Just got my celltrend blood test results back and I am positive for 6 out of 11 tests.

Anti AT1R Antibodies <10.0 U/ml: negative 10.0 – 17.0 U/ml: at risk > 17.0 U/ml: positive 59.4 (positive)

Anti ETAR Antibodies <10.0 U/ml: negative 10.0 – 17.0 U/ml: at risk > 17.0 U/ml: positive 60.7 (positive)

Anti a-1- adrenergic Antibodies <7.0 U/ml: negative > 7.0 U/ml: positive 11.4 (positive)

anti-Muscarinic Cholinergic Receptor 2 - Antibodies <9.0 U/ml: negative > 9.0 U/ml: positive 18.2 (positive)

anti-Muscarinic Cholinergic Receptor 3 - Antibodies <6.0 U/ml: negative 6.0 – 10.0 U/ml: at risk > 10.0 U/ml: positive 16.3 (positive)

anti-Muscarinic Cholinergic Receptor 4 - Antibodies <5.0 U/ml: negative 5.0 – 7.0 U/ml: at risk > 7.0 U/ml: positive 47.6 (positive)

Very pleased that I have something solid and evidence to my dysautonomia and CFS symptoms. My next step, no idea exactly but trying to get to see a specialist in autoimmune diseases and possible talk about IVIG.

Wow, so many answers could be answered from such a simple set of tests.

- Andy

[DizzyGirls]

Just curious, what type of autoimmune disease were you tested for?  I haven't seen these before.  My daughter just tested positive for Hashimoto's disease (autoimmune hypothyroid).  I suspect she might have other autoimmune issues as well. 

[StayAtHomeMom]

What kind of test was this? I have never seen it. It would be interesting to check out. 

[Weary]

Keep in mind that everyone I have so far heard of tests positive on anywhere from 1 to 10 autoimmune markers on the CellTrend test. Hope I am proven wrong and lots of people post to say they have had zero postive results. In addition, apparently a lot of "normals" test positive as well. There are some disorders like CFS where there is a statiscially but very small difference in presence of some autoantibodies. compared to "'normals" but data a bit shakey. plus these they show up in a variety of different hard to predict condition, so not specific either.

but if you have wanted to try IG treatment anyway then what the h***, it might be  bargaining chip to convince a doc who needs a push to order the treatment for you.

[sb4]

@Weary I had the same test minus aA1 and came back negative on all of them. I was just outside the at risk range on M3 and M4, which come up in some POTS papers and A1 is of course the main one so make of that what you will.

[Natops]

@andybonse   Do you live in America? - if so  - did you have to get a doctors script to get this blood drawn or did the lab draw it without a doctors script?

[p8d]

@WearyI only had the  Anti AT1R Antibodies come up positive.  I also have UCTD, looking like lupus from blood tests.  I take Plaquenil for the UCTD which has helped with the fatigue a bit.  I am currently considering subcutaneous IG but my neuro is checking with Dr Kem in Oklahoma who discovered these antibodies about my specific issues.  SQIG apparently doesn’t cause asceptic meningitis.

.  @Natopsmy neurologist ordered the blood draw as a miscellaneous test but the lab associated with that organization would not spin it to serum and give it back to me.  I had to go to a medical college clinic for that.  Apparently places that do transplants do this with some regularity.  Shipping was a nightmare.

[bombsh3ll]

On 8/1/2018 at 6:03 PM, andybonse said:

Just got my celltrend blood test results back and I am positive for 6 out of 11 tests.

I am really interested in this too! Did I read in one of your posts that you are also in the UK? How did you go about arranging these tests, was it complicated? I can easily get a colleague to take my blood - well, actually getting it out of my volume depleted veins is no small task - but the logistics of getting it to where it needs to go under the correct transport conditions I imagine is more difficult.

Do keep us posted on whether you get anyone to treat you with IVIG - I would also like to explore this but think the chances on the NHS would be minimal.

B x

[Weary]

Thanks to the two folk that posted with minimally positive tests at CellTrend! That def helps some. I will try to ask around some more and get some more data on percent positives. 

 

Will be interested to gear what dr kem says about your case 

 

Will be curious to hear 

[green]

What do you mean by saying 'root cause'?

 You now have some evidence that your symptoms can be explained by autoimmunity. Autoimmune disorders are disorders wherein the immune system attacks the body, or attacks some molecule that the body produces endogenously and serves some functional role.  So, you have, perhaps, traced one further link back in the chain of causes responsible for your symptoms, but I would think that the autoimmune condition itself was caused. And if the autoimmune condition was caused, then what caused that? Perhaps that is the root cause, or perhaps there will still be some further cause for that further thing.

Perhaps this means that you can look forward to focusing on treatments that treat autoimmune POTS, or, you can now research possible treatments by researching about autoimmune disorders more broadly, instead of just focusing on POTS? I hope so. 

I think it is an interesting thing to think about. You could have POTS caused by an autoimmune condition caused by a gene/pesticide interaction caused by the fact that people won't stop dumping pesticides into the water supply, caused by bad farming practices made possible by an underprotective EPA. What is the root cause in that story?