Lemons2lemonade

Be careful about taking too much selenium. They use to use it during birthing and learned that it caused precocious puberty so they stopped.

Nerve impulse is roughly na+ in k+ out to create an action potential. I wonder what having a plethora of na+ does to electric impulses within the nervous system.

http://en.m.wikipedia.org/wiki/Bradykinin http://en.m.wikipedia.org/wiki/Hereditary_Angioedema For all you research buffs, I start at Wikipedia and go from there Basically this stuff does the opposite of angiotensin and there are known genetic associated with it.

Estrogen, angiotensin, both globulins.

Saline is a typical solution for orthostasis. If they won't give it to you, tell them you've been pooping for the past 24 hrs straight. You can even throw in vomiting for good measure. But beware of the famotidine injection. Also have them do orthostatic vitals. If they are off you can say, "see I am dehydrated, I need saline" Saline is typically given to me in the infusion room of my drs office and they don't want anyone to know about it. I guess if people did know about it, then they'd all.come in for hangover cures I also get it at urgent care after hours. I just say my pots is flaring and that I need a bag of fluid to combat the tachycardia. Getting saline is a slippery slope though. It only helps for about 24hrs 48max and then you are back to your potsy self. And I could see building up a tolerance to it. So I save it for when I need it, which ends up being about once every 3 months. Also, saline does have its risks- infection, flebitis, infiltration etc. Any time something breaks your skin barrier its a risk. And I imagine picc lines have an even higher risk. When I was working for assisted living here was a guy there whose catheter site had gotten infected without anyone knowing it. The resulting consequences looked like the scene from a horror movie. 2 days later, I came in on my first round to catch him hyperventilating with a pulse of 180 while laying down. The infection from the catheter had gotten into his blood stream and when I found him he was in septic shock.

My Dr's are flying me through some tests before I go to mayo. Yesterday I did my gastric emptying study which consisted of eating a gross radioactive scrambled egg and mayonaise sandwich and 4 hours of hanging out at the dr.s office to get imaged every hour. I spent last night in a sleep lab hooked up to electrodes and am finishing the day portion of the study today. Where, they woke me up at 5am and are allowing power naps every 2 hrs. When I go to sleep, I think they watch my eeg to see if I am actually asleep, and once I am, they come in and wake me up lol. On the plus side they brought me some pretty decent French toast for breakfast, and I just had really good Asian food for lunch-- a meal usually not executed well by hospital meal services

Julie, I also have had my estradiol and testosterone tested. Testosterone was slightly high once, then back to normal.

Julie, have you googled pregnancy and angiotensin ii yet?

Anna, I had a pots attack during my glucose tolerance test that would be consistent with this. Another notable idea is the prevalence of intolerance to carbohydrates and the high amount of sugar type substance within them.

A lot of times when you go in with a chronic illness your doctor will say the dreaded, "what can I do for you today." To which you would like to respond, " how about getting your *** in gear and helping me figure this thing out you insensitive jerk." But instead you say, well let's do a bag of saline. Sometimes a brief argument will follow, but they would much rather give you the saline and pretend to do something. I would suggest that anyone with an uncooperative doctor ask him what his plan is as an alternative, because this nothing crap isn't working for me. **works every time-- I also used this method to get approved for my mayo referral.

They don't want to give it to you because they don't think it is useful. Like why would you want saline? Also newer research is saying that drinking water is more effective than saline--according to my Dr... I've also dropped the pots when talking to people, instead I say ,"my autonomic nervous system doesn't work and there are periods of time where I need saline to increase my blood volume." Nervous system malfunction sounds more serious than pots and it is more relatable.

Jangle, he is ignorant, don't be afraid to use that term. Ultimately, he is saying that his opinion outweighs the viability of the research coming from the top medical organizations in this country. Also remember, he is not a researcher. He is a diagnostician.

If this is an angiotensin ii or ace2 deficiency, why did I become orthostatic in my 20's? This leads me away from gene expression because if it were a defective gene, then the symptoms would have been present since birth. Unless, we are talking about a mutation that is deficient and continuing to copy itself.

You can if you have time Issie and are feeling well enough. That is so thoughtful of you! And yes I soo want them to check my angiotensin ii.

Mcblonde, yes, it happened when I picked up the nasty habit of smoking at bars. Quit and it went away.

No clue Issie. Maybe for those of us who don't faint the vagus nerve is only partially activating which should decrease hr but instead tries to but fails. Triggering more hormone release that overpower the vagus causing faster heartrates. Which sets off the whole shabang. My pots attacks always feel like a tug of war within my body. And the near syncope/ or syncope is the vagus nerve's last pull to win the game.

I have a question, why does fainting resolve these issues temporarily or does it?

This sounds to me more like a positive feedback system that continues to build upon itself until "papa bear" or the vagus nerve comes in and tells everyone to knock it off. By quickly reducing cardiac output which leads to faint. That is my very scientific and measureable explanation. But seriously though, the nervous system and hormonal system building off each other in this manner makes me think positive feedback system.

Oh I love this disease. Nervous system function causes hormonal dysfunction which causes nervous system dysfunction. Or vice versa.

Issie, it was barely high once and is ok now, I also had my estradiol tested and it was ok. I actually have a friend with pcos, and we are much different. Also have had ultrasounds done.

Perhaps something about saline is more sensitive to aldosterone. I.e allowing it to retain more efficiently.

Jangle, another factor here could be the method of saline entry, it goes directly into then blood stream and bypasses the intestinal absorption process.

What, if any abnormalities have been found in your blood tests. No matter how allegedly insignificant. No close calls. Specifically out of normal range. Mine have been: high albumin twice, low vitamin d, high hgb, high hct, low potassium reoccuring and before florinef, high mchc, high testosterone.

Any input on the formation of these from the liver as a precursor to angiotensinogen->angiontenisn ii? Specifically beta globulins, plasmin which triggers ovulation( menstral symptoms?) , properdin(immunoresponse) , shbg (testosterone, estradiol) , transcortin ( cortisol, progesterone and aldosterone, deoxycorticosterone 11 [mineralcorticoid precursor to aldosterone]

Jangle, I finally went and looked up this stuff up. Something noteworthy is the effect of enzymes. Since we are talking about the ace2 precursor to angiotensin ii. Essentially, the role of an enzyme is to reduce the energy required to make a chemical reaction occur. In this case the amount of energy required to compose angiotensin ii out of other molecules. Now if ace2 is high you can expect higher levels of angiotensin ii etc I am curious about angiotensinogen and its globulin precursor.