firewatcher Posted July 16, 2012 Report Share Posted July 16, 2012 http://www.marketwatch.com/story/combined-northeratm-droxidopa-data-from-two-phase-3-trials-confirm-symptom-improvement-in-patients-with-neurogenic-oh-2012-06-21A lot of our docs are trialling this for orthostatic hypotension and it seems to be working.... Quote Link to comment Share on other sites More sharing options...
diamondcut Posted July 16, 2012 Report Share Posted July 16, 2012 Can we ask our Dr's for this or will they say no until it is trialed fully? Quote Link to comment Share on other sites More sharing options...
diamondcut Posted July 16, 2012 Report Share Posted July 16, 2012 Does anyone know if this can help slow your heart rate? Or would this drug be more of a stimulant which would be no good for Hyper POTs? Quote Link to comment Share on other sites More sharing options...
Anoj Posted July 16, 2012 Report Share Posted July 16, 2012 Thanks for posting this! Would this be similar to something like Adderall? Does anyone know if this drug would help/hurt those of us with hyper tendencies? Quote Link to comment Share on other sites More sharing options...
brethor9 Posted July 16, 2012 Report Share Posted July 16, 2012 the article states hypotension so I am thinking it may not work for us hypers......if its more of a stimulant it definately wont work for me...... Quote Link to comment Share on other sites More sharing options...
Kellysavedbygrace Posted July 17, 2012 Report Share Posted July 17, 2012 Thank you for sharing. My doc had mentioned this coming out and I appreciate the update! Quote Link to comment Share on other sites More sharing options...
Anoj Posted July 17, 2012 Report Share Posted July 17, 2012 Well, I'm just curious because Adderall was shown effective for hypers in a recent study. I guess there's the mystery of dysautonomia. It doesn't always make sense. Quote Link to comment Share on other sites More sharing options...
diamondcut Posted July 17, 2012 Report Share Posted July 17, 2012 Is Midodrine classed as a stimulant does any one know, what is its catergory it falls into? Quote Link to comment Share on other sites More sharing options...
arizona girl Posted July 17, 2012 Report Share Posted July 17, 2012 Oh my gosh, this is what I always thought was causing hypotension, an inability to produce norepinephrine on standing, since I get hypertension on standing an my norepi almost triples on standing. So, I thought the opposite was happening for those of us with hypotension. I'd never seen that written in the medical literature until this study.Even though the hypertension isn't great, at least it allows me to stand without fainting. The body does amazing things to compensate doesn't it.About Neurogenic Orthostatic Hypotension Neurogenic OH is a chronic neurogenic disorder resulting from deficient release of norepinephrine, the neurotransmitter used by sympathetic autonomic nerves to send signals to the blood vessels and the heart to regulate blood pressure. This deficiency results in lightheadedness, dizziness, blurred vision, fatigue, poor concentration and fainting episodes when a person assumes a standing position. Symptoms of chronic Neurogenic OH can be incapacitating, not only putting patients at high risk for falls and associated injuries, but also severely affecting the ability to perform activities of daily living that require standing or walking. Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted July 18, 2012 Report Share Posted July 18, 2012 It wont be -at least at this stage - tested on POTS that is not neuropathic. As the belief is increasing NE levels will only add fuel to the fire. Seems to work quite well for many forms of OI - being tested in Australia as well. Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted July 18, 2012 Report Share Posted July 18, 2012 Midodrine is a stimulant that is also a peripheral alpha 1 receptor agonist. it is structurally related to some stimulants and over time can promote hypovolumia. Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You can post now and register later. If you have an account, sign in now to post with your account.