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While I've not seen Cymbalta used specifically, it is accepted by ANS specialists that antidepressants may be useful in the treatment of POTS. It's believed that their effect on the central nervous system helps to mediate the Autonomic systems.

See DINET's primary site for information on antidepressants, listed under "what helps".


Selective Serotonin Reuptake Inhibitors and Welbutrin are two groups of antidepressants commonly used in treating POTS.


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I was put on Cymbalta for a few days by my regular doc to see if some symptoms I was having were caused by my Paxil. They weren't and my neurologist switched me back to Paxil for my POTS because he said the Cymbalta may work, but it hasn't been tested yet for effectiveness for POTS. Since I was doing fine on the Paxil, we didn't want to mess with it. Hope it helps though!


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The SSRI class includes:

Prozac, Luvox, Paxil, Effexor, Celexa, Lexapro

Here's a nice comparisson chart of all the available SSRI's and reported effects.


Wellbutrin is in the monocyclic aminoketone class of drugs (generic name: buprorion).

Then there are the tricyclics, including anafranil, tofranil, amytriptaline, etc.--about.com has good info on those:


Nina :lol:

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  • 3 weeks later...


My doctor also wants me to start on this, I have been tried on many different anti depressants but could never tolerate any. I think I will try this. I am currently taking xanax xr for anxiety. Still tacky in am. These are two good sites to get info from, there seems to be alot of positive feedback for Cymbalta, go to

http://depression.about.com. Then go to forums. It only takes like two minutes to join the site, has been very helpful to me. There is also another site I like at http://crazymeds.org.

Very informative with a humourous side. Good luck! :o

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