Net Deficiency Revisited

[ramakentesh]

I think this is a very rare cause of POTS

Sure a straight out mutation by epigenetic NET gene silencing could potentially account for a subset of patients.

[L4UR3N]

This is so interesting because I have long noticed that eating soy (which has estrogen effects) during the luteal phase of my cycle improves my symptoms GREATLY. Never understood why, but now it makes more sense

Well, with the first article, they had no definitive conclusion because the sample (number of women) was too small and they could only follow it for one month. Basically, the researchers observed that if you use a drug to impair norepinephrine transport in young healthy women their autonomic and cardiovascular responses to the standard 4 ANS tests changes over the course of our month. Higher estrogen levels act as a protective mechanism and the sudden drop during menstruation causes a worsening POTS-like response. They don't know why yet. It was actually a good try at explaining why our symptoms are worse when we are right before our periods.

I haven't gotten to the rest yet.

Ramakentesh, what is your collective take on NET deficiency? Does the theory still hold water or are there pieces of that puzzle still missing?

[issie]

Bump.

[issie]

.

[ramakentesh]

maybe.

[Mytwogirlsrox]

Bump