Has anyone been tested for GIP during an OGTT or otherwise?

[Sarah Tee]

There’s some research going on at Vanderbilt University into the release of a chemical called GIP in patients with POTS who have marked postprandial symptoms.

I am wondering whether anyone has been tested for this, maybe during an OGTT or mixed meal test.

I am not sure how hard it is to test for. It’s just a blood test, but is not done commonly, so you might need to be at a university or research hospital, or the blood might need to be sent somewhere specialised.

I’m going to ask my specialist next month whether we can test it.

***

GIP stands for glucose-dependent insulinotropic polypeptide. Amongst other functions, it dilates the veins etc. in the abdomen to increase blood flow to the gut after we eat.

This is the preliminary study:

https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.121.17852

Bigger study is underway:

https://clinicaltrials.gov/ct2/show/NCT05375968

[RecipeForDisaster]

Very interesting! I’d get tested if they had it in Boston. I know I do much worse after I eat literally anything…

[MikeO]

@Sarah TeeI am going in to my Doc next week and am going to ask for a stimulated C-Peptide test which will require a glucose challenge (OGTT or MMT). I have been kinda reading some of the same studies and does make sense to me or at least my post-prandial hypotension.

Sure if i ask my Dr for the glucose-dependent insulinotropic polypeptide levels he will deny this one. Sure he would not know what to do with the data.

[MikeO]

@Sarah Teejust had a after thought. Tirzepatide (Mounjaro) is a GIP/GLP-1 antagonist for diabetes. One of the effects is weight loss (don't need that) but if it has a positive effect on post-prandial symptoms i would soo be on board. I am sure i can at least get my Doc to consider the drug.