diamondcut Posted January 5, 2013 Report Share Posted January 5, 2013 I have tried quite a number of anti histamines, and reacted not so good with quite a few, i seem to be doing ok with Diphenhydramine even though this is one of the older class of anthistamines. I wondered if anyone else was on this?I have read that it is not so effect as some of the newer classes if H1's but if this suits me at the moment i have to go with that. Quote Link to comment Share on other sites More sharing options...
Kellysavedbygrace Posted January 5, 2013 Report Share Posted January 5, 2013 I use dye free benedryl as an extra antihistamine when I am crashing. I don't seem to notice a lot of difference but it does seem to help relax my sympathetic overstimulation. According to my mast cell doc of the newer class OTC H1s and H2s Claritin and Pepcid seem to be the most well tolerated. Have you tried both? Also, what has been your bad reaction to the anthistimines you've tried? Quote Link to comment Share on other sites More sharing options...
Katybug Posted January 6, 2013 Report Share Posted January 6, 2013 I take hydroxyzine every night (h1) and plus high dose cimetidine (h2). When I have break through symptoms I supplement with benedryl. I find that that benedryl is pretty effective. Quote Link to comment Share on other sites More sharing options...
brethor9 Posted January 6, 2013 Report Share Posted January 6, 2013 At first Benadryl was the only H1 I could tolerate too......all the others just made me way sicker .....but I kept at it and finally after taking really small doses throughout the day (like 5mg at a time) I have been able to tolerate Claritin. In my case though I have found that its the Zantac and gastrocrom that are more important for controlling a lot of my symptoms......but I still use Benadryl for breakthrough symptoms. My MCAS specialist is more in favour of mast cell stabalizers rather than high dose antihistamines because they can be hard on the system and for us with hypovolemia can wreak havoc with hydration Quote Link to comment Share on other sites More sharing options...
Kellysavedbygrace Posted January 6, 2013 Report Share Posted January 6, 2013 Bre, is he considered to be a mast cell stabilizer? If so, any chance you know which metabolites it blocks? Quote Link to comment Share on other sites More sharing options...
brethor9 Posted January 6, 2013 Report Share Posted January 6, 2013 the gastrocrom is the mast cell stabalizer Quote Link to comment Share on other sites More sharing options...
micheller Posted January 6, 2013 Report Share Posted January 6, 2013 I'm pretty positive I have Mast cell. But Benadryl knocks me out cold. I'm always so groggy when I get up that I don't notice if it helped with any symptoms. I haven't tried the standard H1, H2 treatment. Is it OTC dosage or higher prescription dosage? Quote Link to comment Share on other sites More sharing options...
diamondcut Posted January 7, 2013 Author Report Share Posted January 7, 2013 Thanks for that,Its strange it has taken me weeks to tolerate Benadryl and others did exactly that and made me worse, other anti histamines have caused all sorts of problems, Ketotifen which i believe is an H1 and Mast cell stabliser really helped with the nausea but i had this strange numb tinglness in my hands. Now i should think that is not a dangerous side but it not nice. So i have settled with the more old fashion Diphenhydramine.Thats interesting Brethor what you say about mast cell meds being more important to help with POTS symptoms. So far Klonopin and Gastrocrom havnt given me any problems touch wood.H1's are so difficult to get started on. Quote Link to comment Share on other sites More sharing options...
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