Merrill, Thank you for your welcome. Sorry for being so vague, it's just alot of symptoms, and I tend to ramble. Apologies in advance. Before pregnancy my pulse was around 60 bpm resting, 90 ish bpm standing - on Zebeta (5 mg 2x a day), 140+ bpm - when I wasn't taking Zebeta. BP averaged at 105/65 with little to no variation with postural changes. Starting at week 7 of pregnancy, I had uncontrolled vomiting and colonic inertia, I couldn't eat and ended up losing 31 lbs by week 13. My tachycardia worsened because of the nausea and vomiting, and really worsened after my doctor took me off beta blockers for the remainder of the first trimester. Basically, I could not move much at all. I ate ice constantly to try to keep hydrated, because I couldn't keep down electrolyte based drinks. I also had migranes, but I'm assuming that had nothing to do with POTS since I never had one before being pregnant. Second trimester nausea and vomiting have improved as expected. Main complaints include continued colonic inertia, and POTS issues (as high as 140 bpm again) including : lightheadedness/loss of orientation with postural change, dehydration, muscle spasms pain, and weakening (I've had this all through my 7 year stint with POTS, mostly controlled by the Zebeta before pregnancy, worsening recently when I came off the beta blockers). I sometimes pass out trying to have a bowel movement, and frequently have to stop trying althogether because I'm hyperventilating. I can barely walk from my bed room to my kitchen without having to lie down to recover, which was why my doctor wanted to retry beta blockers to give me some quality of life again. When taking the Toprol (25mg 1xday), I experienced painful vascular headaches, vascillations in BP when standing, but my pulse evened out for the most part. I also started having blackouts (loss of orientation and then consciousness); and collapsing (no loss of consciousness, my legs just collapsed). While collapsing I'd break out in a sweat, hyperventilate, lose my sight in one or both eyes and lose my hearing for up to an hour. When I caught my breath I'd feel the blood rushing up my neck into my head and pounding really hard. I recently switched cardiologists because the one I was seeing seemed pretty darn lost when the Toprol didn't work (I'm new to my city and in process of finding and educating new doctors). In the meantime, my OB has given me the go ahead to restart Zebeta, so I have at a VERY LOW dose (2.5 mg). I'll see a new cardiologist next week, and ask them about the dosing and safety Non-pharmecutical I've tried a variety of things to help with the lack of bowel movements, which seems to have some success. I wear support hose, and do resistance leg excersizes in bed. I can sit up for a few hours each day, and when I feel a vascular headache coming on I eat salt and that does help sometimes. I usually drink gatorade mixed with water and benefiber, but when I get backed up I can only drink water because I get nauseous. I'm really looking for general advice: what to look out for, what questions should I be asking my doctors, that sort of thing. I read some of the other pregnancy related posts and appreciated the warning about hypertension (I would never have thought that possible since my BP is so low), and the info on epidural and c-section vs vaginal delivery. I'd also like to know if anyone has successfully taken beta blockers during pregnancy. If so, which ones? If not, is it because beta blockers are a bad idea? Has anyone had the kind of bad reaction that I had? Do other drugs have better effects for anyone? I know we are all different with our POTS, but I'd at least like some info to be able to suggest to my docs. I know this is an essay and I apologize once again. This has been anything but an easy pregnancy for me, and I was kind of expecting it to get a little easier.