I have both and it took a long time to get the correct diagnosis. I was diagnosed with POTS about 10 years ago but nobody caught the IST until this year. I switched to a new EP that made me wear a holter monitor for two weeks and it showed up. Previous holter monitor was only worn for 24hrs. I was so surprised because I didn’t know it was possible to have both. Have never been able to tolerate beta blockers because they lower my blood pressure too much. Was put on Corlanor and it has improved my life.