I am hyperandrenergic and before my diagnosis I was on Cymbalta briefly for radiculopathy. I had a rather severe reaction with all of the hyperandrenergic symptoms (tachycardia, hypertension, sweating etc). Cymbalta was not a good med for me with my over abundance of norepinephrine but I know others who have had better luck with it. I take and tolerate Wellbutrin with no side effects. Best of luck to you finding the right fit.