For those of you who have POTS, I was wondering if you know the cause of your POTS. I realize that many people either can't or don't get to the point of having to discover the cause of their POTS, but if you do know I'd like to hear what the doctors discovered. The main reason I am interested is I am trying to see if I can find a connection between my POTS and the miscarriages I have had. I realize that miscarriages are very common, many occuring before a woman even knows she is pregnant. And I know that there isn't any evidence that POTS actually causes miscarriages and that there are many women who have POTS and also have successful pregnancies. But I am wondering if there is a connection for some of us. My POTS has a autoimmune cause. My body makes antibodies for M2 muscarinic acetylcholine receptors. These receptors are found in the heart, throughout the brain, the uterus, and many other places in the body as well. Because my M2 receptors don't work right, the messages from my brain to my body get blocked and this causes my POTS. I am wondering if this same root problem of my POTS also causes my miscarriages. Do any of you know the cause of your POTS? And if you don't mind sharing, have you had any difficulty getting pregnant, or maintaining a pregnancy? If you have had a miscarriage, was a cause ever determined? I have been working on researching this online, but unfortunately there isn't much information. Most of the studies have been done on rat uteruses. Which, although it can shed some light, it can't be translated directly to people. P.S. My heart goes out to those of you who have gone through the painful loss of a child in a miscarriage.