Report What causes fatigue in dysautonomia? in Dysautonomia Discussion Posted Friday at 01:23 AM REgardless of whith form of dyautonomia you have, many of the typical dysautonomia symptoms cause fatigue: low blood pressure, high heart rate, high blood pressure, lack of oxygen to the brain. The cause of the fatigue would probably depend on your particular etiology. Many of the medications we take - like beta blockers - also cause fatigue. I found that once I got on the right meds and got moving my fatigue decreased dramatically.