Fatigue is by far the toughest part of my illness and I so wish I could get a handle on it. It's the symptom that makes me feel like the world is existing without me. That being said, I have a few tricks up my sleeve that tend to work for me. I hit a wall - fast + hard - every day by about 6pm. If I start to feel really tired throughout the day, usually exasperated by working on my computer and being sedentary for a couple hours, I try to force myself to get up, go for a walk, do some cleaning, etc. Seems to by me a little more time. After 6pm or so, this isn't really an option. If I have to do something in the evening and can't wriggle out of it, I use provigil (aka nuvigil) a wakefulness promoting med that really helps, though there is a price pay... in my case it results in an increase in muscle tension pain, and some irritability. Smoking marijuana also helps, though it too tends to make my pain worse, and obviously the high isn't conducive to most situations. Otherwise, I usually spend about 15 hours/day in bed, and even though I hate it, when I'm super fatigued, there's no place else I'd rather be. Thanks for posting this... hoping to hear more from other folks.