After reading of the miraclous effects of d-ribose on mitochondria, I decided to try it (I have POTS and Pandysautonomia, autoimmune disease, neuropathy, hyperandrenergic POTS, severe low blood volume, wacky high NE, low sodium, dehydration, gastroparesis w/malabsorption, severe tachycardia with loop monitor, untraceable D without huge rx supplementation, among a host of imbalances and cns issues now, and super severe fatigue, plus suspected mito for which i am to be evaluated). After a week, I am disappointed in that shortly after taking it, I feel like I am severely crashing and achey like I have the flu. It claims to improve energy, but i experience the opposite. I cannot get out of bed. It's kind of debilitating, although i have deteriorated as if I have some progressive form of POTS, but the d-ribose just put me over the top. I read it can cause hypoglycemia in diabetics. My fasting blood sugar has been running slightly high around 125, but diabetes runs on both sides of my family. A recent spinal tap showed high glucose on my csf - a pretty definite indication of diabetes. bummer! I don't like most foods since I got POTS and there just isnt much left i can eat. i cannot digest fats. Further, although I have severe daily tachycardia and an implanted loop monitor, i experienced a severe drop in all my vitals last night, and my pulse dropped 100 bpm to 25 but was hit 50 max for several hours. Ok, i feel bradycardic nowadays below 90. my bp also tanked and i stayed up all nite afraid to go to sleep, and considered going to the ER before my heart stopped. Right n0w, I am up to 78. I cannot get out of bed. I had such hopes (admittedly, I am at the point i am grasping at straws), for the d-ribose. Has anyone had any experience with D-ribose. it is supposed to have the opposite effect and give you energy. What about co-Q10? Thanks! Please reply.