Goschi Posted June 4, 2014 Report Share Posted June 4, 2014 Recently, my cardio thought again about giving me Florinef, but once again, he considered my BP being still a bit to high. When he saw my disappointment, he replied: "Don't worry too much about it, Florinef won't probably help you, as it has no vasoconstricting effect and thus won't prevent venous pooling."I always thought Florinef acts right this way? But he denied again. Anyone knows about the mechanisms of Florinef...? Quote Link to comment Share on other sites More sharing options...
DeGenesis Posted June 4, 2014 Report Share Posted June 4, 2014 Florinef (fludrocortisone) acts indirectly as a vasconstrictor by increasing the sensitivity of peripheral alpha-receptors. Florinef increases plasma volume. This can help indirectly with venous pooling because while blood is pooling in your extremities, there is more reserve to perfuse your upper body.Florinef gave me heaches while laying down that were only relieved by elevating my bed. It also gave me high blood pressure.When is your blood pressure high? If it is only high when standing (orthostatic hypertension), then Florinef, as well as IV saline and salt loading, can be beneficial because hypovolemia can sometimes paradoxically cause high blood pressure due to excess sympathetic activity triggered by low cerebral perfusion. This approach definietely requires close observation by a doctor as well as at home BP monitoring.Hope this helps. Quote Link to comment Share on other sites More sharing options...
DeGenesis Posted June 4, 2014 Report Share Posted June 4, 2014 The ignorance of many cardiologists to the pharmacology of many commonly used drugs in cardiology and related fields of medicine is somewhat baffling to me. Quote Link to comment Share on other sites More sharing options...
Goschi Posted June 4, 2014 Author Report Share Posted June 4, 2014 Thanks a lot, DeGenesis!!My BP got almost only higher (up to 150/100) when I was upright , though this didn't happen every time. When I was supine, it was always pretty perfect (115/75).With the recent use of a Betablocker (1.25mg Bystolic every morning), the BP never goes higher than 130/90 when I am standing, supine it even tends to get to low (100/65).I will discuss the use of florinef with my neuro, he seems to be more willing to give it a try!! Quote Link to comment Share on other sites More sharing options...
Anoj Posted June 6, 2014 Report Share Posted June 6, 2014 it is not a vasoconstrictor. it helps the body retain salt & water.florinef raised my BP more than any other drug i took. Quote Link to comment Share on other sites More sharing options...
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