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Tolerance To Metoprolol? Worse Tachycardia


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I've been on Metoprolol for over a year and it's kept my tachycardia in check...at rest my HR is between 75-85. Then all of a sudden just over a week ago my resting HR zoomed up to 98 resting and 122 standing despite having taken the metoprolol. At first I thought the increased HR as a reaction to starting midodrine. I went off the midodrine a few days ago to give my heart a rest but it's still freaking out. I can't think of anything else that would be causing this higher heart rate. The only other change to my medications has been going off birth control this month. Can you get exacerbated tachycardia from going off the pill? Can you body build up a tolerance to beta blockers? Because thats they whole reason I'm taking metoprolol...to keep my heart rate down.

I'm EXHAUSTED from having a contantly pounding heart, in addition to the chronic fatigue POTS gives me every day. Anyone have any insights?

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My body built up a tolerance against metoprolol but much quicker. It worked just ten days for me. My cardio advised to up the dose and I git great benefit for another ten days and boom more tolerance. That kept going on until I was at a dose of 300mg per day. As that made me too tired I went back to 200mg. After starting octreotide I weaned off of the beta's but it turned out I need Paxil to keep standing hr in control.

In my opinion you'd best check with your cardio on what to do to keep your hr in control! Best wishes!

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