Pots, Mcad And Autoimmune I Found The Link Between Them!

[RichGotsPots]

Increased levels of free Ig light chains have also been detected in various inflammatory diseases. It is important to note that, in contrast to increased levels in lymphoma patients, these Ig light chains are polyclonal. Recent studies have shown that these Ig light chains can bind to mast cells and, using their ability to bind antigen, facilitate activation of these mast cells (Redegeld (2002)). Activation of mast cells results in the release of various pro-inflammatory mediators which are believed to contribute to the development of the inflammatory disease. Very recent studies have shown that Ig light chains not only activate mast cells but also dorsal root ganglia (Rijnierse, 2009)) and neutrophils (Braber and Thio (2012)), expanding their possible role as mediators in inflammatory disease.

[looneymom]

Hey Rich,

Can you post the article? I want to read it.

Rachel

[Guest Hanice]

You are gonna change the world mister! Keep it up!

[sue1234]

I'd be interested to hear what you have found on it. All I can find is light chains are related to things like amyloidosis and other things that cause some organ failures. I'm not sure if anyone here has anything that serious, or at least the majority here don't. So I must be missing something. Can you elaborate?

[RichGotsPots]

http://www.nature.com/nm/journal/v8/n7/full/nm722.html

[RichGotsPots]

http://www.jni-journal.com/article/S0165-5728(09)00012-5/abstract

[Guest Alex]

Rich,

I think the idea of the immunoglobulin-free light chain involvement into MCAS and inflammatory autoimmune diseases has been around for a while. I'll post some articles below - not sure if you've seen them.

My question for you would be: How do you see this as playing a role in POTS? Also, correct me if I'm wrong but usually MCAS is associated with hyperPOTS (elevated standing NE levels) while the autoimmune diseases seem to be correlated more with neuropathic POTS and some doctors/researchers think that these are different entities (with some overlap in certain patients). I'm guessing you're making some other connections I'm not seeing yet?! Help me/us out

http://www.tufts.edu/~ttheoh01/mastcellsinflammation.pdf (2004)

http://mastcellmaster.com/documents/Mast-Cells-and-Inflammation/Mast-cells-inflammation-NYAS.pdf (2006)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1798389/ (2006)

http://www.wikilite.com/wiki/index.php/Immune_stimulation_and_elevated_polyclonal_free_light_chains

Alex

[looneymom]

I'm really glad you brought this topic up. The other day I found some doctor's research on PANDAS and he is was stating that mast cell can be part of PANDAS. Which would make sense with hypersensitivity in PANDAS patients.

Alex thanks for posting these articles again. I keep reading and filing them away.

Rachel

[RichGotsPots]

Alex- yes IgG have been implicated in MCAD before and they are also well known in Amyloidosis, which can caused POTS.

In that Paragraph though it brings together MCAD, Inflammatory disease (i.e. autoimmune connective tissue disease), Dorsal Root Ganlia (which is the begining of the autonomic nervous system which is located in the spine. This is the part I match up to POTS)

[Guest Alex]

Gotcha Rich.

So this would actually be involved only in certain POTS subsets ...if any. Hopefully some researchers are looking into this.

I have tried to find the 2009 article by Rijnierse - the one referenced on wikipedia, or any other articles linking the IgLC to the DRG but I haven't yet. Do you happen to have any other resources you can point me to? I'd like to read more about this.

I do know there is research about the loss of nerve cell bodies in the DRG (all of which has been detected at autopsy ) in patients with acute autonomic and sensory neuropathy (AASN), acute autonomic, sensory and motor neuropathy (AASMN), paraneoplastic syndrome and Sjorgen's, and these illnesses have been known to cause different degrees of dysautonomia.

Also, have you ever considered contacting Dr Vernino with your findings? He might be interested in hearing from you given that he has dedicated so much time to studying AAG and related conditions.

Alex

[RichGotsPots]

Alex- yes only for certain subsets. I forgot to add on my symptom theory post Chiari Malformation. For example EDS people who have pots have a high possibility of MCAS and Chiari. But Chiari is another subset where the nerve damage at the Dorsal Root Ganglia. But there are bound to be many other ways of causing that damage especially autoimmune.

I recently contacted started contacting a few researchers and haven't gotten any response. I can't remember if I contacted Verino, but I contacted literally everyone at Vandy. When I contact none autonomic specialist at the top of their field I have about 75% luck with startingnup conversations with them so far I have only ever emailed with one researcher in America. It's a pretty stuff group.