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The Effect Of Time-Of-Day And Sympathetic α(1)-Blockade On Orthostatic Tolerance.


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Interesting! May be a piece of the puzzle as to why so many of us note increased symptoms in the morning.

Thanks for posting.

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In terms of orthostatic hypotension this makes a lot of sense. Midodrine is indicated for OH patients because it is an a1 agonist so in other words it activates the a1 receptors preventing OH.

However, I don't have OH, in fact I have orthostatic hypertension, which is why midodrine did nothing for me.

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