Comparative Clinical Profile Of Postural Orthostatic Tachycardia Patients With And Without Joint Hypermobility Syndrome

[Katybug]

Thought this might be interesting to migraine sufferers:

Comparative clinical profile of postural orthostatic tachycardia patients with and without joint hypermobility syndrome.

Kanjwal K, Saeed B, Karabin B, Kanjwal Y, Grubb BP.

Source

Division of Cardiology, Section of Electrophysiology, The University of Toledo Medical Center, Toledo, OH 43614, USA.

Abstract

BACKGROUND:

Autonomic dysfunction is common in patients with the joint hypermobility syndrome (JHS). However, there is a paucity of reported data on clinical features of Postural orthostatic tachycardia syndrome (POTS) in patients suffering from JHS.

METHODS:

This retrospective study was approved by our local Institutional Review Board (IRB). Over a period of 10 years, 26 patients of POTS were identified for inclusion in this study. All these patients had features of Joint Hypermobility Syndrome (by Brighton criterion). A comparison group of 39 patients with other forms of POTS were also followed in the autonomic clinic during the same time. We present a descriptive report on the comparative clinical profile of the clinical features of Postural Orthostatic Tachycardia patients with and without Joint Hypermobility syndrome. The data is presented as a mean+/-SD and percentages wherever applicable.

RESULTS:

Out of 65 patients, 26 patients (all females, 20 Caucasians) had POTS and JHS. The mean age at presentation of POTS was 24+/-13 (range 10-53 years) vs 41+/-12 (range 19-65 years), P=0.0001, Migraine was a common co morbidity 73 vs 29% p=0,001. In two patients POTS was precipitated by pregnancy, and in three by surgery, urinary tract infection and a viral syndrome respectively. The common clinical features were fatigue (58%), orthostatic palpitations (54%), presyncope (58%), and syncope (62%).

CONCLUSIONS:

Patients with POTS and JHS appear to become symptomatic at an earlier age compared to POTS patients without JHS. In addition patients with JHS had a greater incidence of migraine and syncope than their non JHS counterparts.

[roxie]

Thanks! This is interesting.

When I read the section on POTS in Dr Tinkle's EDS book he mentioned that POtS tends to hit earlier when their is EDS than when there isn't.

[jangle]

Interesting to note that only female patients were JHS and POTS.

[Kellysavedbygrace]

Thanks for sharing! Interesting.

[peregrine]

The POTS/JHS person here says "thank you!"