Histamine/antihistamine, No And Fatigue/exercise Intolerance

[firewatcher]

https://www.jstage.jst.go.jp/article/bpb/35/1/35_1_91/_article

Apparently histamine released by exercise (not by mast cells) protects against fatigue...at least in mice.

I wonder how much of my post-exercise fatigue is due to my antihistamine?

[Chaos]

http://www.mastocyto...ut%20slides.pdf

This is the transcript of Dr. Afrin's Mast Cell presentation in Canada last year. I thought it was interesting when reading it that one of the physician participants in the discussion there mentioned how in the "old days" they would have people exercise 2-4 times a day to "burn off" histamine. Maybe your article explains what "really" happens, even though the net result may be the same as what that doc was describing.

Personally, I stopped my Xyzal and Singulair about 3 weeks ago, but I'm still having PEM/PENE. Also stopped my Wellbutrin so my whole body has been just totally messed up.

Thanks for posting this! Maybe that's why exercise makes some people on here feel so much better.

[anaphylaxing]

Interesting. I find I feel better overall with exercise BUT if I overdo it or overheat then it triggers my reactions. But overall worthwhile so far

Who knows what they'll figure out about all of this someday!

[Katybug]

For what it's worth, my post-exertion fatigue and exercise intolerance started before I started my antihistamines.

[firewatcher]

My exercise intolerance (cardiac) also began before I ever started daily antihistamines, but I have had one symptom that is new to the last several years: when I exercise, my muscles fatigue at an unnaturally fast pace. I am stronger than most, but have no "strength endurance" anymore, there is not a gradual decline of strength but a sudden inability to do any more. Then the post-exertion pain is more like an injury than soreness. My cardio suggested lack of O2 in the microvasculature due to either ANS dysfunction or beta blockade. This article may suggest another theory. Most of my problems are, in fact, in my quads...

[Katybug]

I experience the same "strength endurance" issues you describe, firewatcher. I will ok doing what I'm doing until all of a sudden it's just not ok anymore and I feel like I'm gonna fall down, drop what I'm holding, etc.

[Millerla]

I also have those issues fire watcher, I did still go to dance during the school year, and some warmups just killed me, I just stopped while everybody else kept going. Then during my exercise tolerance test, all of a sudden my legs were on fire and I just could not pedal the bike anymore. My mom took me out on a wheelchair because my legs wouldn't support my weight.

I haven't been on antihistamines though, other than the occasional Zyrtec for seasonal allergies.

[Chaos]

Same here. Frustrating because it makes no sense based on anything I know about progressive exercise/strength training/conditioning. When I was doing cardiac rehab, instead of being able to tolerate more weight and more reps each week, I was hitting that wall of "it just won't move again" at fewer reps and less weight every time I went. After 6 weeks of doing weights, I was actually able to do less than when I started the program- as far as weights were concerned. I could do a lot more cardiac activity though.

Also frustrating because when I tell my doc that I'm weak, he does the manual muscle test but that doesn't reflect what I'm trying to describe since it's only a one time resistance.

[brethor9]

same symptoms as you katybug and firewatcher.....I also had exercise intolerance issues before POTS but managed to always push through....maybe that was part of the problem.....as for the muscle weakness...my one specialist thought it could do with lactic acid or the fact there may not be enough oxygen getting to the muscles. I also had a smooth muscle biopsy titre done and it came back elevated.....none of my specialists have been able to figure out the significance.....

[Katybug]

Yes, yes, yes...CHaos, that's exactly what happened to me. I was trying to use a workout DVD that's made for people over 50 (I figured it might have the modifications I needed to get going, and it did). The DVD shows 3 people doing each exercise: one beginner/easy, one medium, one advanced/harder modifications. The exercises focus on toning and balance and protecting yourself from hurting your back while doing this. The first week, I was able to do each exercise at about the medium level for the full set of reps. The second week, I was struggling to do the medium level and often had to drop back to the beginner modifications. By the third week, I was having to take breaks and couldn't complete all the reps. (These workouts are only 20 mins!!) The docs give me the " " look and don't address it. As someone said, the quick manual test they do making you resist there pressure on your arms and legs is fine so they don't seem to worry about it but I sure know its not right. All my life I have been able to achieve progressively positive results to cardiac and strenght training until now. We have rules out myositis with labs. I am suspicious it has to do with a build up of inflammation in my body.