Annaliese Posted April 19, 2012 Report Share Posted April 19, 2012 My POTS was sudden onset and started during late pregnancy. After 18 months i finally convinced a dr to measure Angiotensin II. Well i got the result back today and my standing Angiotendin II levels are high. It's interesting because in preeclampsia they have also found angiotensin II autoantibodies. Btw i first presented with extreme anxiety and chest pain with very high hr and high bp. Over 18 months my BP has gradually decreased and is now low. Quote Link to comment Share on other sites More sharing options...
Chaos Posted April 19, 2012 Report Share Posted April 19, 2012 Interesting! Thanks for sharing this. How are your POTS symptoms now? Did you have preeclampsia in pregnancy? Would have been interesting to see what your angiotensin ll levels were when you had the onset of POTS. Quote Link to comment Share on other sites More sharing options...
Annaliese Posted April 19, 2012 Author Report Share Posted April 19, 2012 Yes i was diagnosed with preeclampsia but i dont think it really was true preeclampsia in that the high bp was posture dependent. Unless of course i have a genetic mutation ( a supersensitivity somewhere?) that leads to preeclampsia being posture dependent. Quote Link to comment Share on other sites More sharing options...
Annaliese Posted April 19, 2012 Author Report Share Posted April 19, 2012 Oh,pots symptoms getting marginally better with time. Health was 0/10 but now 3.5/10 id say. Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted April 19, 2012 Report Share Posted April 19, 2012 Great find! How does licorice and inderal effect you? Quote Link to comment Share on other sites More sharing options...
Annaliese Posted April 19, 2012 Author Report Share Posted April 19, 2012 Inderal was great in the beginning when i had high bp. It decreased chest pain and anxiety. Now i dont take it anymore because 1) i believe i have low blood volume and inderal decreases renin activity and 2) i now have low bp and inderal worsens that. Licorice i have in my cupboard but havent tried yet because to be honest i forgot i had it! Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted April 19, 2012 Report Share Posted April 19, 2012 Licorice seems to actually stimulate at-1 receptors in the kidneys according to one study causing a release of aldosterone. Was dizziness a feature of your POTS? Quote Link to comment Share on other sites More sharing options...
Annaliese Posted April 19, 2012 Author Report Share Posted April 19, 2012 Never was dizzy when i had high blood pressure in the beginning. But now i often get dizzy (as in about to faint). Quote Link to comment Share on other sites More sharing options...
Annaliese Posted April 19, 2012 Author Report Share Posted April 19, 2012 Oh, my upright renin and aldosterone were also very high but normal whilst supine. Quote Link to comment Share on other sites More sharing options...
firewatcher Posted April 19, 2012 Report Share Posted April 19, 2012 Preeclampsia and POTS share hypovolemia as well. There was a study, that I can't find now, that mentions the chronic low blood volume persists after giving birth and creates a predisposition to hypertension later in life. I wondered why these women did not all get POTS or why POTS patients did not all have preeclampsia. There is some mechanism that is different for us. I thought it would make a good clinical trial, but never pursued it.BTW, I did not have pregnancy hypertension until the actual labor and delivery. Quote Link to comment Share on other sites More sharing options...
issie Posted April 19, 2012 Report Share Posted April 19, 2012 Just bumped up another thread on a connection to pre-eclampsia and autoantibodies to ACE II also. Quote Link to comment Share on other sites More sharing options...
Annaliese Posted April 20, 2012 Author Report Share Posted April 20, 2012 Hmmm, thinking since my renin and and aldosterone also went very high with ortho stress, perhaps its just a normal response to low blood vol (ie pooling) as apposed to ang 2 synthase autoantibody being present. Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted April 20, 2012 Report Share Posted April 20, 2012 In the original article by Vandy they had high ang ii and low renin/ald. But high sympathetic activity Quote Link to comment Share on other sites More sharing options...
issie Posted April 20, 2012 Report Share Posted April 20, 2012 In the original article by Vandy they had high ang ii and low renin/ald. But high sympathetic activityI wish they would check my levels - since having the low renin/aldosterone issues and terrible sympathetic activity. You would've thought that the ARB would have worked on me - but, it didn't. Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted April 20, 2012 Report Share Posted April 20, 2012 what about alpha lipioc acid? Quote Link to comment Share on other sites More sharing options...
issie Posted April 20, 2012 Report Share Posted April 20, 2012 what about alpha lipioc acid?Still taking the B1 before I add that as just adding that by itself if your B1 levels are too low - will make you really sick and you won't tolerate the alpha lipoic. I do plan to add it - but, not just yet - still need more B1 on board.Issie Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted April 20, 2012 Report Share Posted April 20, 2012 read somewhere (maybe) that it can boost NO levels in some. Quote Link to comment Share on other sites More sharing options...
issie Posted April 20, 2012 Report Share Posted April 20, 2012 read somewhere (maybe) that it can boost NO levels in some.Yeah, that's what it's supposed to do. It would make some POTS people really sick (People listen here - some POTS people have too high levels of NO already.) But, for me I think I need to increase my NO levels. Jangle is doing great on it.Issie Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted April 20, 2012 Report Share Posted April 20, 2012 good to hear. Quote Link to comment Share on other sites More sharing options...
jangle Posted May 8, 2012 Report Share Posted May 8, 2012 Interesting that you also mentioned that your levels were taken while standing. I have to wonder about other people's reports if they were taken while standing or not.As for me I don't think I'll get a doctor to actually measure my angiotensin ii levels, and realistically speaking that is something that can only be measured by a well trained and experienced technician, which I believe only exists in research settings/specialized areas. Quote Link to comment Share on other sites More sharing options...
Annaliese Posted May 8, 2012 Author Report Share Posted May 8, 2012 Yeah, im lucky because my dr is into research. Its a tricky business measuring and interpreting hormone levels. It took me ages to find a dr willing to measure ang 2. Quote Link to comment Share on other sites More sharing options...
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