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Melatonin Effects On Cerebral Autoregulation And Pial Vessel Tone

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Melatonin was at one stage being touted as a wonder drug for POTs - particular the hyper kind - and in more recent times cerebral autoregulation has been a focus of study on POTS by some groups so this may be of interest:




Research on the efficacy of Melatonin in POTS is ongoing.

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Annaliese, that's interesting - I rarely sleep good - and hardly ever sweat. I know I must be low in melatonin - but, the couple of times I tried it - instead of sleeping good it made me have weird dreams and I felt like I was falling or something - sort of anxious. It hasn't been something I wanted to experiment with again.


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  • 2 weeks later...

This might be of interest to some. I'm trying to figure out the dose needed to get on this ASAP.

Effects of melatonin on peripheral nerve regeneration.

Turgut M, Kaplan S.


Department of Neurosurgery, Adnan Menderes University School of Medicine, Aydin, Turkey. drmturgut@yahoo.com


In the available literature, there are thousands of studies on peripheral nerve regeneration using many nerves of several animals at different ages with various types of lesions and different methods of evaluation at certain time of follow-up. Despite many experimental data and clinical observations, there is still no ideal treatment method enhancing peripheral nerve regeneration. In clinical practice, various types of surgical nerve repair techniques do not frequently result in complete recovery due to neuroma formation, lipid peroxidative damage, ischemia and other factors. Recently, a number of neuroscientists demonstrated that pineal neurohormone melatonin (MLT) has an effect on the morphologic features of the nerve tissue, suggesting its neuroprotective, free radical scavenging, antioxidative, and analgesic effects in degenerative diseases of peripheral nerves. At present, it is widely accepted that MLT has a useful effect on axon length and sprouting after traumatic events to peripheral nerves. Our studies using various experimental injury models clearly suggest positive effects of MLT on the number of axons, thickness of myelin sheath by inhibition of collagen accumulation and neuroma formation following traumatic events to peripheral nerves, myelination of developing peripheral nerve after intrauterine ethanol exposure. Nevertheless, further experimental and randomized controlled clinical studies are vital to identify the clinical use of MLT hormone. This is an overview of recent patents and current literature in terms of the effects of MLT on peripheral nerve regeneration based on a critical analysis of electrophysiological, biochemical and light and electron microscopic findings, in addition to functional observations.

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