24 Hour Urine Sodium In Pots

[firewatcher]

J Pediatr. 2012 Mar 14. [Epub ahead of print]

Twenty-Four-Hour Urinary Sodium Excretion and Postural Orthostatic Tachycardia Syndrome.

Zhang Q, Liao Y, Tang C, Du J, Jin H.

Source

Department of Pediatrics, Peking University First Hospital, Beijing, China.

Abstract

OBJECTIVE:

To investigate whether 24-hour urinary sodium excretion could be an indicator of the effectiveness of salt supplementation in children with postural orthostatic tachycardia syndrome (POTS).

STUDY DESIGN:

The patient group comprised 30 children with POTS, and the control group comprised 10 healthy children. Serum sodium and 24-hour urinary sodium excretion were measured in all children, and the relationship between 24-hour urinary sodium and symptom severity was analyzed in the 30 patients. At 1 month after initiation of salt supplementation, the receiver operating characteristic curve was used to explore the probability of correctly discriminating responders to salt supplementation from nonresponders using 24-hour urinary sodium excretion as an indicator.

RESULTS:

Patients with POTS had lower 24-hour urinary sodium excretion than controls (P = .022). Symptom severity was negatively correlated with 24-hour urinary sodium excretion (OR, -0.754; P = .000). The receiver operating characteristic curve demonstrated a sensitivity of 76.9% and specificity of 93% for correct prediction of responders and nonresponders to salt supplementation when a 24-hour urinary sodium excretion of 124 mmol/24 hours was used as the cutoff value.

CONCLUSION:

Our results indicate that 24-hour sodium excretion of <124 mmol/24 hours is an indicator of the effectiveness of salt supplementation in children and adolescents with POTS.

Copyright © 2012 Mosby, Inc. All rights reserved.

[ramakentesh]

Vandy are doing some interesting work on sodium in POTS right now.

[Annaliese]

I saw in one article they were using 24 hr sodium as a surrogate marker for blood volume. I wonder how well 24 hr sodium is actually correlated with blood vol?

[jenglynn]

Of course I don't remember specifics, but I have had this test 3 times at Mayo- and was supposed to do it this week for a follow up appt. but some kidney dysfunction derailed it- so my neuro won't even see me until this has been done. All 3 times I have had it down the sodium level has been very abnormal- so that is why he needs it done for the follow up. Go back April 13th and hope all is well that time!

Jen