issie Posted March 14, 2012 Report Share Posted March 14, 2012 I just got my March 2012 Life Extension magazine and in it is an article on Olive Leaf and it's benefits. It says that it can lower blood pressures, increase NO levels, works to inhibit angiotension converting enzyme, works like a calcium channel blocker. I've mentioned before that Life Extension feels that the baseline medical community standards of what is considered hyper-tension is too high - right now it's acceptable at 140/90 mmHg. But, Life Extension feels like the acceptable should be 115/75. Which is really low compared to medical community's acceptable limits. They have had many articles showing why just tiny amounts of increase above this level can cause problems to veins and arteries.It has always been my go to when I start to feel like I'm getting sick. So, now another good reason to continue taking it. Hoping it will get my bp down some more.I know this won't work on you with OI but it might be very good for us that are HyperPOTS with possible low NO and high angiotension levels.http://www.lef.org/m...ey=olive%20leafThis link didn't take me to the page that I'd written down - but, hopefully you can do a search and look at the article.Issie Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted March 14, 2012 Report Share Posted March 14, 2012 It contains an antioxidant that boosts norepinephrone transporter protein. Quote Link to comment Share on other sites More sharing options...
issie Posted March 14, 2012 Author Report Share Posted March 14, 2012 Okay, so does that means that us with high NE levels it might NOT be so good? But, for others maybe so. Issie Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted March 14, 2012 Report Share Posted March 14, 2012 It means the opposite. It would be good for high NE. Although ace inhibition might be bad. Quote Link to comment Share on other sites More sharing options...
issie Posted March 14, 2012 Author Report Share Posted March 14, 2012 Oh, okay. Why would ace inhibition be bad? Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted March 15, 2012 Report Share Posted March 15, 2012 http://www.ncbi.nlm.nih.gov/pubmed/18848665 INTRODUCTION:The norepinephrine transporter is responsible for the intracellular uptake of (131)I- iodometaiodobenzylguanidine ((131)I-MIBG), which is used for the diagnostic localization and treatment of pheochromocytomas as well as other tumors such as neuroblastomas and carcinoids. This agent is variably delivered into tumor cells by the norepinephrine transporter, but few studies have shown treatments that work to increase norepinephrine transporter activity. The objective of the present study was to test the possible beneficial effects of hydroxytyrosol in enhancing norepinephrine transporter function, which may have implications for its combined use with (131)I-MIBG in the diagnosis and treatment of pheochromocytomas. METHODS:Rat pheochromocytoma PC12 cells were labeled with [(3)H]-norepinephrine in the presence or absence of different concentrations of hydroxytyrosol, a naturally occurring compound with strong antioxidant properties, followed by measurements of uptake and release of radiolabeled norepinephrine. RESULTS:Hydroxytyrosol pronouncedly increased norepinephrine transporter activity, with the rapid onset excluding effects on norepinephrine transporter expression levels. Concomitant with increased norepinephrine transporter activity, hydroxytyrosol caused a decrease of both spontaneous and evoked norepinephrine release, indicating that it affects pre-existing plasma membrane-associated norepinephrine transporter, rather than the incorporation of novel norepinephrine transporter molecules into the plasma membrane. CONCLUSION:Hydroxytyrosol potently enhances norepinephrine transporter activity in pheochromocytoma PC12 cells, suggesting that combinatorial therapy employing hydroxytyrosol may improve the effectiveness of (131)I-MIBG as a diagnosis and treatment modality Quote Link to comment Share on other sites More sharing options...
issie Posted March 15, 2012 Author Report Share Posted March 15, 2012 Rama,Having a brain fog night - what is the significance of this study. Are the high NE levels there to suppress things like sarcoidosis? I had a radiologist tell me that when he saw people with multiple tumors that are unexplained - his first thought is neuorfibromytosis - he said he had seen it in the POTS people that he had seen in his career. He felt like that was one of the causes of POTS for those people. Just wonder if there is a connection to high NE.Also still wondering about why ACE inhibition - why would that be bad if you have high bp's.? Wouldn't that be like an ACE inhibitor that is sometimes given for high bp's.? Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted March 15, 2012 Report Share Posted March 15, 2012 Not really - its just talking about how an antioxidant in olive leaf can increase norepinephrine transporter function which may be reduced in some POTS patients. Quote Link to comment Share on other sites More sharing options...
issie Posted March 15, 2012 Author Report Share Posted March 15, 2012 Well, I just took one - so we'll see if it brings mine down.Issie Quote Link to comment Share on other sites More sharing options...
issie Posted May 10, 2012 Author Report Share Posted May 10, 2012 Another possible help.Issie Quote Link to comment Share on other sites More sharing options...
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