ramakentesh Posted February 15, 2012 Report Share Posted February 15, 2012 Some articles that may be of interest:http://circ.ahajourn...bstracts/A16180Blockade of Norepinephrine Transporter Magnifies Tachycardia and Worsens Symptoms in Postural Tachycardia Syndrome http://circep.ahajou...t/1/2/103.shortAltered Sympathetic Nervous Reactivity and Norepinephrine Transporter Expression in Patients With Postural Tachycardia Syndromehttp://journals.lww....ascular.11.aspxNorepinephrine Uptake Mechanisms in Cardiovascular Diseaseshttp://jnnp.bmj.com/.../3/339.abstractCardiac neurotransmission imaging with I-meta-iodobenzylguanidine in postural tachycardia syndromehttp://hyper.ahajour...4/1203.full.pdfHormonal Influences on Cardiovascular Norepinephrine Transporter Responses in healthy womanhttp://onlinelibrary...11.07552.x/fullAngiotensin-(1–7) through Mas receptor up-regulates neuronal norepinephrine transporter via Akt and Erk1/2-dependent pathways Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted February 15, 2012 Author Report Share Posted February 15, 2012 while angiotensin II reduces NE reuptake:http://www.ncbi.nlm.nih.gov/pubmed/1423026 Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted February 15, 2012 Author Report Share Posted February 15, 2012 http://jpet.aspetjournals.org/content/167/2/291.shortSo could the faulty NE reuptake phenotype in POTS be a consequence of abnormal ang II levels? Quote Link to comment Share on other sites More sharing options...
jangle Posted February 15, 2012 Report Share Posted February 15, 2012 Well it does seem that angiotensin ii has the same effect as atomoxetine as an NET inhibitor if I'm reading this correctly. This is a large volume of information for me to absorb I'll have to reread through it all. I've actually never touched base with what the NET is or what the theory of its association is with POTS. Quote Link to comment Share on other sites More sharing options...
issie Posted February 15, 2012 Report Share Posted February 15, 2012 Well those of us with high NE (over 600 with standing) and probable NET dysfunction, what does this mean for us?I know Jangle, I read it all and will have to read it all again. LOLRama, can you break it down for us?Issie Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted February 15, 2012 Author Report Share Posted February 15, 2012 Actually this is something I wrote up a while back. I just found it and thought Id post it today. Too hot outside to do much else!First study found that SNRIs worsended symptoms in POTS patients.Second study talks about the prevalance of the finding of NET abnormalities in POTSThird study demonstrates that POTS patients tested had reduced expression of NET in their forearms.And then there is the connection to Angiotensin II - which modulates NE reuptake and perhaps NET expression.The first study from Vanderbilt suggested that ang II was associated with the reduced NE reuptake phenotype in POTS. Quote Link to comment Share on other sites More sharing options...
issie Posted February 15, 2012 Report Share Posted February 15, 2012 Thanks, Rama. Always love to get more info - just understanding it . . . .that would be good too. LOLIssie Quote Link to comment Share on other sites More sharing options...
issie Posted May 10, 2012 Report Share Posted May 10, 2012 bump - up more angiotension II and NET connections.Issie Quote Link to comment Share on other sites More sharing options...
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