Lenna Posted February 9, 2012 Report Share Posted February 9, 2012 Lenna,So sorry. Would you son be up to being in one of the studies?IssieNo, not really. What we really wanted was Stewart's advice about Losartan. We eventually went ahead and started Dan on Losartan anyway, kind of blindly but it seems to have worked out. Quote Link to comment Share on other sites More sharing options...
issie Posted February 9, 2012 Report Share Posted February 9, 2012 Lenna,Sometimes, you just have to try things. Even with his opinion you wouldn't have really known unless you tried it and it seems to have worked. So all is good - for now - Right? Issie Quote Link to comment Share on other sites More sharing options...
Lenna Posted February 9, 2012 Report Share Posted February 9, 2012 All good. And no hard feelings towards Dr. Stewart - his research has given Dan his life back to some extent. I just wanted to point out that seeing Dr. Stewart isn't as easy as deciding to make the 1500 mile trip! Quote Link to comment Share on other sites More sharing options...
julieph85 Posted February 9, 2012 Report Share Posted February 9, 2012 I live about 4 hours away but I guess I could use my sister in laws address in manhattan? Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted February 9, 2012 Report Share Posted February 9, 2012 Id just tell him lived within two hours LOL.Just as a reminder - angiotensin II has only been found to be low in a subset of mainly female POTS patients that tended to have lower than normal body mass index. Quote Link to comment Share on other sites More sharing options...
issie Posted February 11, 2012 Report Share Posted February 11, 2012 In POTS there is often vagal withdrawal rather than activation.My sister who has CFS has looked into having a vagal nerve stimulator put in. It's one of the treatments being tried for that. She decided not to at this time. But, interesting that there is that connection with POTS too, Quote Link to comment Share on other sites More sharing options...
issie Posted February 11, 2012 Report Share Posted February 11, 2012 Perhaps aldosterone secretion is mediated by the parasympathetic nervous system. Therefore a faulty pns would create the environment of low aldosterone.I believe that indeed the faulty pns is due to high angiotensin ii levels and that correcting that should ne the focus of treatment. Maybe it isn't a compensatory mechanism to low aldosterone.It would be interesting to find out if these two statements could be confirmed. I'd love to know where the high angiotension levels come from if it's not in the kidney axis and if the pns is the cause of low aldosterone.Issie Quote Link to comment Share on other sites More sharing options...
issie Posted June 27, 2012 Report Share Posted June 27, 2012 bump up, just because.Issie Quote Link to comment Share on other sites More sharing options...
issie Posted June 27, 2012 Report Share Posted June 27, 2012 A little research into spiralactone shows that it lowers testerone and could potentially imbalance your hormones. There are also some new warnings out that it is causing breast cancer - particularly in men. Although, some of the sites I went on says some women are connecting it to their cancer also. Some studies showing increased tumors also.I don't know if it is a mast cell degranulator - but, I did an experiment last night - which went really bad. I tried one - because of the terrible edema I've been having and I was up all night really sick. I took all my mast cell things and still feel bad this morning. It really did make me pee a whole lot and my edema is better and my high blood pressure is down. But, I feel awful. I hurt in my back where my kidneys are and feel tight in my throat and chest. Scared to try it again. So, on to the next experiment and chalk this one up to a bad idea. I don't know if this reaction was connected to the fact that my aldosterone levels are already too low and it lowered it more or whether it was due to a mast cell reaction. Could have just been a coincidence. But, with the new warnings on the meds and how I felt - not really wanting to go there again.Just thought I'd put what experience I had with it here. For me, bad experiment. Getting more pieces of my puzzle figured out though. Issie Quote Link to comment Share on other sites More sharing options...
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