Annaliese Posted November 22, 2011 Report Share Posted November 22, 2011 Hmmm, ive just learned that anaesthetic blocks the AChR receptor. In autoimmune dys there is an AChR receptor antibody which does all the damage-there seems to be a connection. It kind of makes sense to me the body might react to surgery by producing antibodies against the AChR receptor. But why then after a virus would the body attack those same receptor sites? Is it that the postviral autoimmune response produces lots of antibodies and the AChR antibody is just one of them? Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted November 22, 2011 Report Share Posted November 22, 2011 I think that particular receptor is suspected but only 6% of POTS patients tested in one study had it, and even then at very low levels. Quote Link to comment Share on other sites More sharing options...
Annaliese Posted November 22, 2011 Author Report Share Posted November 22, 2011 Ah, Ok. Thanks. Ramakentish there's one thing ive been meaning to ask you. In hyper pots where you tend to get polyurea, what is the mechanism for this? I dont understand it because the sympathetic nervous system is going crazy -the flight and fight response tends to stop urination so why all the peeing? I used to have high standing bp (and hence i think i had hyper pots) but over the year its gotten lower and lower but the one thing that hasnt changed is the thirst-drink-pee cycle. Florinef seems to reduce this. Any insights you have would be much appreciated. Quote Link to comment Share on other sites More sharing options...
Schorobi Posted February 14, 2012 Report Share Posted February 14, 2012 Annaliese, I don't understand this either...I have read however that increase sympathetic activation causes your body's volume status to be reset. I no longer have the polyuria on the combination I mentioned on the previous post and my weight has been stable and nearly back up to my baseline. Quote Link to comment Share on other sites More sharing options...
julieph85 Posted February 14, 2012 Report Share Posted February 14, 2012 I think the polyuria is actually a result of the polydipsia. Increased sympathetic activity causes excessive thirst which leads to frequent urination. Quote Link to comment Share on other sites More sharing options...
Annaliese Posted February 15, 2012 Author Report Share Posted February 15, 2012 How come it only happens when standing though? Quote Link to comment Share on other sites More sharing options...
ramakentesh Posted February 15, 2012 Report Share Posted February 15, 2012 Apparently there is only firm evidence of excessive sympathetic activity when upright. Quote Link to comment Share on other sites More sharing options...
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