Hey, thank you everybody for your helpful replies!
Yes, increasing to 60mg caused the side effects, but then going back to 50mg didn't stop them (that's why I think it would have happened with 50mg, too, just maybe a bit later). Yesterday I tried 5mg-5mg-5mg, which was ok (no stomach issues, only a bit of gut issues). I am careful though and I see the potential risks. Thank you @p8d for extra cautioning me. (And yes, I'd be interested in your Mestinon experience.)
My understanding is that hyperadrenergic POTS is difficult to treat. My doctor gave me the impression Mestinon is the only shot. I have other diseases, too, and it seems they exclude other meds. (I will ask about alternatives nonetheless...)
@bombsh3ll, yes, I treat the burning eyes with drops which works. The diarrhea wasn't funny though, so I decreased the dosage to the already mentioned 5-5-5. I already have low body water, so losing more via diarrhea might be problematic (besides not getting the nutrients you need). This dosage gives barely side effects and helps a bit with the POTS. But I still consider lowering the dosage/stopping. But:
Both. That's why I don't want to give up. I felt nearly normal. It felt like I could do things I couldn't do before because being upright causes so much trouble. I have to take IGG, and afterwards POTS gets much worse, which was much better with Mestinon. If I eat "too much" (especially carbs), the POTS gets worse, and Mestinon helped with that, too. I imagine if I had been able to increase Mestinon, that might have disappeared altogether. It's not like I was like healthy again, but it was like "Oh I have POTS? Really? I nearly forgot about that." There are some more "subtle" POTS symptoms of course...
Re. numbers: Without Mestinon my HR was 145 after 1min of standing; I had to stop a poor-man's-TTT (Schellongtest) after 7min latest because I felt like fainting. With Mestinon, HR rised to 120 after 5min, which still isn't grand, but!, and although I wasn't symptom-free, I could finish the test.
There's only one downside (besides the side effects): During sleep my HR is already low with ~45 bpm, 50mg Mestinon lowered that slightly more to maybe 38-40bpm.