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I just wanted to mention something that my lactation consultant had told me about.  It's something called D-MER and it can cause depression, anxiety, or even agitation while breastfeeding, especially during the letdown.  I mention this on this forum because it is a relatively new condition that is not understood, but may be caused in part by dehydration.  I know many of us are dehydrated or fluid issues may be a problem, so it might be more common in those with POTS.  I think I had this while breastfeeding my first; I had a much harder time than "normal" people and maybe this is why.  This time around it seems easier.  Just thought it might be good to bring up in case anyone was breastfeeding with POTS and might have these symptoms.  It could explain part of it.  

https://d-mer.org/

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