Daily Persistant Headache And Allodynia

[looneymom]

I may have found the cause of my son's headache. The connection I am finding has to do with CamKinese, Glutamate, and NMDAR receptors. Through research, I have learned that High CamKinese levels can do so much damage. It helps regulate the NMDAR receptors and these help regulate the glutamate in the brain. Through testing, I already know that Tyler has high levels of both of these things. Tyler's doctor did check him for NMDAR NR1 antibody subsets but it came back negative. However, plasma exchange will effect the test results so he may be positive. If you have a daily headache, you might want to see if your doctor will check the glutamate in the neurotransmitters test. Tyler was very high and so was his Norephrinphrine. Excessisve glutamate can cause pain. So i started researching and came up with some interesting articles that coud explain why Tyler's has the high glutamate levels.

However, Tyler's headache levels have dropped down some due to a medication called Nemanda. Our doctor has called in the higher dosage due to a study I found. Allodiynia is a form of CRPS. Tyler acutally mets the criteria for this diagnosis. So I wanted to share the study and some of the other articles that influence glutamate levels in the brain. Tyler has been checked for celiac antibodies and this test was negative. He was on a dairy free and gluten free diet for 6 weeks and this did not make a difference. I am also using NAC and Magneium to help supress Tylers glutamate and NMDAR receptors. Here are the articles. Maybe these will help someone else.

http://www.rsds.org/pdfsall/Sinis_Birbaumer_Gustin.pdf

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318689/

http://pharmrev.aspetjournals.org/content/63/1/35.full

http://toxsci.oxfordjournals.org/content/68/1/9.full

http://www.psychiatryadvisor.com/magnesium-an-essential-supplement-for-psychiatric-patients/article/362253/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044191/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044191/

[looneymom]

Here are a couple more research articles on Nemanda.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762361/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC534915/

[SarahA33]

Rachel,

I am SO happy to hear that Tyler is finally finding some relief with these migraines. This is so interesting..these are great articles you are finding. Thank you for sharing this... I started getting Botox injections 6 months ago and it's been the only thing in a decade that's been able to decrease the frequency and severity of the migraines..

I hope that you and your family had a nice Christmas and a Happy New Year. Think of you guys often

Just thought I'd also suggest that you should go back to Med School!

Sarah

[looneymom]

Hi Sarah,

Glad the Botox is helping. I wish Tyler could do it but since Botox is a live virus. It's a no, no for him.

[looneymom]

This article also discusses Nemanda and some other stronger medications used for allodynia. I thought I had all these articles together in the same place.

http://paindr.com/wp-content/uploads/2012/06/Opioid-Nerve-Pain_Fudin-ZORN.pdf

[angelloz]

I have daily headaches and Scalp allodynia but am super sensitive to medications. Even supplements. I take things in VERY small doses. You mentioned magnesium and I am trying to increase this. My I ask what NAC is?? I have always had migraines..but the daily head pain and pressure etc... began with the autonomic problems.

I hate the things that go one with my body but I must say the constant head pain and migraines are by far my worst symptom.

I also want to thank you for taking the time to share information ad all of your research! You are amazing!!

[looneymom]

Here is a good article that explains what NAC is. There are studies on NAC and what is has been used for. I'll see if I can find some of the studies and post them.

http://www.lef.org/magazine/2010/5/n-acetyl-cysteine/page-01