Katybug Posted September 10, 2014 Report Share Posted September 10, 2014 Has anyone who tried midodrine actually ended up with lower bp? My neuro put me on it about a month ago for narrow pulse pressure (my bp was in the 90/76 range sitting and 90/80 standing.) That is lower than I had been in about 2 years and the first time I had narrow pulse pressure. Since I've been on the midodrine, I have experienced some of the lowest bps of my life....an all time low of 64/42 at my immunologist's office last Tuesday and that was an hour and a half after I took my midodrine. Just wondering if anyone has experienced a paradoxical effect from this med. My bp was obviously becoming low anyway so I'm not sure if the midodrine just isn't helping what was already a trend or if it's making it worse. Whichever.....I feel awful! :-[ Quote Link to comment Share on other sites More sharing options...
Raisin Posted September 11, 2014 Report Share Posted September 11, 2014 I know that for me, the midodrine doesn't raise my blood pressure at all. I thought it would help raise it but it stays the same. But, it does help me tremendously in the function factor. Without it, I think I pretty much have only a teaspoon of blood actually reaching my lungs and my brain. Lol. I wonder what others experience also. I have noticed my diastolic is going below 60 alot but this is at night when the midodrine should have "worn off"? Quote Link to comment Share on other sites More sharing options...
Mermaid Posted September 11, 2014 Report Share Posted September 11, 2014 Same here (as Raisin), midodrine doesn't have any effect on my heart rate or BP. I also think it helps me to 'think' better, I don't notice much difference in visible blood pooling symptoms though. Quote Link to comment Share on other sites More sharing options...
Katybug Posted September 11, 2014 Author Report Share Posted September 11, 2014 What's odd is my bp is actually better during late night when the midodrine should be gone. It's odd. Thanks for your responses. Quote Link to comment Share on other sites More sharing options...
E Soskis Posted September 11, 2014 Report Share Posted September 11, 2014 Yes - there is a paradox with midodrine. Initially, my pressure rises and I feel better, think better, and function better. As soon as it begins to wear off, my pressure drops again (often lower than before) and I feel rotten. The positive lasts anywhere from 1-3 hours and the negative lasts until I take another midodrine! Quote Link to comment Share on other sites More sharing options...
hoop311 Posted September 12, 2014 Report Share Posted September 12, 2014 i take midodrine on and off because I have orthostatic hypotension and labile hypertension - i end up taking my bp to decide what to do - I would absolutely agree that it helps with my ability to think - today my bp was low and i struggle tremendously to get out the door to work - i almost backed into the closed garage door! i am super crabby right now about things...but am grateful for the midodrine! Quote Link to comment Share on other sites More sharing options...
Macca Posted September 12, 2014 Report Share Posted September 12, 2014 I get positive benefits from Midodrine, but only for 2-3 days and then it causes me to get big drop in BP and I feel awful for a day or two afterward. It's weird! Quote Link to comment Share on other sites More sharing options...
wilsonh5 Posted September 12, 2014 Report Share Posted September 12, 2014 My daughters doctor is taking her off of it because it doesn't seem to be doing anything. My question is, she is being weaned off, how are we going to know if it was helping will there be a "red" flag?Thanks Quote Link to comment Share on other sites More sharing options...
Katybug Posted September 12, 2014 Author Report Share Posted September 12, 2014 My understanding is that midodrine is very short acting which is why you can take it during the day and stop it at night to prevent supine hypertension while sleeping. I'm not a doctor, but I would think that based on this, you would notice rather quickly if her bp is terribly low or her symptoms are significantly worse once she's off of it. I would think you'd see it within a day or two. Quote Link to comment Share on other sites More sharing options...
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