Lactate In Blood Test Related To Anti-Histamines?

[diamondcut]

I had to go to the ER with high sugar levels and Keytones yesterday as i am type I Diabetic and i couldn't get them on track for about 24 hours, so thought it was better to be safe than sorry. Anyway the long and short of it they got me on a drip, stabilised my sugar levels, and it was brought to my attention that my acidity levels were fine but my Lactate level was high at 3.2.

Now when i start reading up on this there are many explanations, Mitochondrial diseases being one that keeps coming up. The Dr said it could just be a fluke and nothing to worry about but as i have been on so many different drugs this year can this type of thing cause readings like this in the blood.

I posted about Claritin not liking me last week and now I have been taking Rinitadine for 4 days and i must say i am so hot body temperature wise and clammy with flushing i do not think it is agreeing with me also. I am abnormally hot so something is not right and i am slightly wheezy tonight. Is this the MCAD flaring up because of the Rinitide in my system, could this then raise Lactate levels somehow? It just seems strange how my Lactate levels have never been a problem before.

I have read that maybe try taking Nasolcrom first as a mast cell stabiliser, this could be the best step forward.

Also my Dr said that Amitriptyline does contain H1 and H2 blockers already in it. Does anyone know if this is true?

[RichGotsPots]

Have you heard of Singulair? They use this for asthma, for people who get asthma from allergies and they also use it for MCAD but its not over the counter..

[arizona girl]

I'm sure you already know this but people who have diabetes often develop neuropathy. An inability to control body temperature is a sign of autonomic neuropathy. Also if you are always running a low grade fever it could point to other immune issues. I think there are many drugs out there that can cause the blood sugars to get off. Maybe one of these newer meds your trying bump your sugars off.

Are you on oral diabetics or just insulin. High lactate can also be a sign of acidosis which can happen with certain diabetes drugs. I'm on gluemetza, and I watch out for that.

[diamondcut]

Im actually only on Insulin, I had all the usual autonomic testing carried out a little over a year ago, i was told my POTs was related to the EDS and that it was not neuropathy from the Diabetes. How true this is i do not know, i have a feeling it could well be both. The testing i had to rule out neuropathy was putting my hands in ice, whilst BP and heart rate were measured, and a few other tests that i forget about noow, i had a whole range of gastric emptying scan performed also as they were concerned that i had possible gastro paresis- again came back fine. I have read on here that skin biopsies should be carried out to check for small fiber neuropathy. Do you think this is something i should push for?

Rich-

I have heard of Singulair yes, if i was to take that from my Dr, do you think taking that along side a Mast Cell stabliser could help with all these reaction i get to drugs. I am struggling so much with daily migraines that is panics me i will never be able to tolerate a drug for them!!Then what do i do.

Maybe a stupid question but again do many POTs people react badly to Singulair?

[arizona girl]

Yes, I do believe a skin biopsy and/or qsart test are the gold standard for sfn. My doc now does both as neuropathy can be patchy.

I also have had elevated lactate. The protochol for me on that was to do a f/up test to see if it was still elevated. So maybe ask you doc for another one and see if it is still elevated. That may lead to other testing for acidosis or other conditions associated with elevated lactate.

However the fact that you do have eds may be the cause most of you pots like symptoms. It can cause stretchy vessels and blood pooling which then cause pots like symptoms. I may have some mild hypermobility, but I don't think that plays into any of my symptoms. My causes are immune defects with autoimmune disease attacking my connective tissues. Even though eds is genetic it also is a connective tissue disease. Have you investigated that route for treatment. Symptoms of eds may be managed differently. We do though have members here that have both eds and sfn. Maybe they can let you know how they manage their eds.

I don't remember the name of the test, but there is a test to see if your body can metabolize certain classes of medication. Some people are missing an enzyme or something, so that might be something to look into if you are having problems with meds.

Anyone remember the name of that test?

[diamondcut]

Ive just bought one of those kits from 23 and me that a member on here said is definately worth the investment for. Maybe that could help steer me in the right direction!

In regards to the lactate i will for sure have it looked at again to see if it was indeed a fluke or if there is something else possibly going on.

I would say i do suffer from terrible blood pooling as my feet can blue with in seconds of sitting on a chair, or if i put one fot in the air and one down, one looks normal the other purple in less than 2 seconds!!! I really struggle to lift my arms any higher than my head as to it just so much hard work and on my TTT my heart rate just went through the roof when i did this. Then on the other side of thing i have had the diabetes for 17 years now, i suffer from a lot of Nueropathic pain in my my legs, particularly at night time. I also suffer from Vulvadynia which to me is just an extention to the nerve pains in my legs traveling all the way up to between my legs, i dont see why it needs its own name even LOL! I have been told it more likely to be the the EDS (conective tissue disorder) that causes this not nueropathy. But maybe I should not just settle for that explination. Usually what the drs tend to say to me when i push this is "well we treat all the symptoms the same anyway."

Im hoping to start a trial on Lyrica as my next one on the list soon...

When you say you have immune defects with autoimmune disease attacking your connective tissues, does your condition have a name and can i ask how you manage yours? When i think back to all the bloods that were taken from me when being diagnosed with POTs, i can remember talking to my Dr who at first thought perhaps i had a type of autoimmune problem and he did request certain bloods to be taken for this. I am pressuming that is how you were diagnosed with these types of problems?

I think i need to push for a SFN to rule this in or out for sure.

[arizona girl]

Hi, I will get back to you on this after my company leaves next week. But you can search my post and read what I've posted on the topic. I've covered a lot of it already. Have to go and I'll be gone the rest of the day.

[diamondcut]

Thanks Arizona girl for your information, will have a read of old posts.

[RichGotsPots]

I haven't heard of anyone with POTS reacting bad to Singulair yet... I read the recent post on here from a transcript from Dr Afrin. In that transcript he says there are tons of MCAS/MCAD people who have different reactions to the mast/antihistamine meds and that he usually experiments until they get a good combo. He even uses some cancer/chemo drugs to try to kill the mast cells but says it's hard. I would try to get to Boston to see him or one of the specialist there. There are a lot in that area..

[diamondcut]

Rich I wish i could, I am in the UK

I am tempted to have telephone consultations with top guys in the states if it did come to that.

I can go to my GP this week though and ask him for Singulair. Becuase i am not Asthmatic I wonder what would be the best way to approach him to give this to me?

If i explain i am having a lot of bad reactions to meds (which he knows about anyway) Should i explain the Mast cell Activiation is part of my EDS/POTS problem and i believe something like Singuliar could benefit my breathing and act as a stabliser.

But thank you for telling me about it any way Rich.

.

[issie]

Diamondcut,

For the mast cell issues, have you tried Nasal Crom? It's a mast cell stabilizer. You spray it in your nose. I'm also finding that quercetin, vit C and B-Complex is helping too. There is also an herbal by Solaray called "Respiration" that helps with the allergy things. I'm still having to use the Claritin at night. But, not using the H2 that much. I'm okay with Claritin, thank goodness.

Sorry Rich, but Singular is too strong for me. It makes me feel worse. I know - I have to be the odd one. I was able to take it a couple of years ago - but, as my system has gotten more sensitive - it's a no go. My husband takes it and finds it works great for him, he also has asthma. It would be worth a try diamondcut. We won't know how we will react, until we try something.

Diamondcut, do you by any chance have endometriosis? I had vulvodynia - until I had my hysterectomy and no longer suffer with that. So many of my problems ended with my hysterectomy. The hysterectomy was one of the worst things I've gone through - but one of the best things at the same time. No more pain - such a relief. Endometrosis was horrible. They are now thinking that endometrosis is another sign of mast cell disorders. I do know that hormones play a big part in it as with POTS.

Issie

[diamondcut]

Hi Issie

Nasal Crom is one that people have said to try since posting, Just bought some online now so at least i can give it a go without involving my GP. I too seem to be on a viscose circle here of becoming more and more sensitive to each drug. Did you start on just one spray a day?

Its strange really but all my real evident problems stared at 23, I was having this 24/7 Nausea, headaches and then problems down below all at the same time! Ever Dr told me they were no way related what so ever, until 5 years later they agreed the EDS was causing the pain which all intertwines with the POTs.

I have never had Endometriosis and i was fully investigated down there, I did have chronic cervicitis that they had to laser twice when i was 24, and really the Vulvodynia was terrible after that. I couldn't sit on a chair for too long because of the pressure. It was a miserable time and i am thankful the Amitriptyline helps now.

I still get days there where it hurts but it is not 24/7 like it used to be.

Thats very interesting that after a Hysterectomy your Vulvodynia stopped. You would think because of the trauma in that area it could possibly get worse.

Would you agree that Vulvodyia is a type of Nueropathy that we seem to get because of our connective tissue disorder?

[diamondcut]

Issie

With the Sodium Cromoglicate, are the eye drops effective, or does it have to be tablet or nasal form?

[issie]

Diamondcut,

It may be that the surgery you had damaged some nerves and that could cause some of your pain. My hysterectomy actually did some damage to my nerves there and I think that's what took away my pain. Whether or not EDS plays a part in this, I can't say. My hysterectomy was my 8th abdominal surgery and hopefully my last one. The doctor was very well aware of all my issues and I had a ghost surgeon who went through my bowels, bladder etc. to make sure not a speck of endometrosis was left. The only way for them to find endo is with surgery. If they didn't do a scope to look around, there's no way for you to know if you have it or not. Most people with it have horrible, painful mensus. I hope you don't have it - that's for sure!

I do only use the Nasal Crom once a day. You may start out with only one squirt in one nostril. I use one in each nostril. There is also a gastro crom that people take internally. I do have some Ketotifen eye drops - I don't use it alot, but ocassionally. There is a whole lot of trial and error - as you've discovered. What will work for one, won't work for another. Hope the Nasal Crom helps to stablize you more. Try adding those few supplements and see if that helps. I've discovered that a whole lot of my problems are food related. With my genetic testing, I've discovered why this is. There are certain food familieis that my body won't break down properly or the components break down and turn into something my body doesn't like. For a few things glutamates and sulfur and sulfites. I have to take these things out of my diet and supplement rountines. This won't be easy, because they are my staple foods. I was thinking I was eating so healthy - but was making myself sicker - with these "healthy" foods. I don't have it all figured out and have so much more to learn. But, looking forward to incorporating these new things into my life. Hope the 23&me testing works out well for you. Be sure to download you raw data into the other program that it talks about, because the majority of my info came from that additional program. (Plus, I have a friend who is helping me to understand what it all means.) You can hire someone to help you to interpret your results ----it will seem like Greek. Way over my head at the moment - but, I'm learning.

Issie

[diamondcut]

Well I again i have learnt something new today, I had one of those lovely Ultra sound type probes up there to have a look at whats what. They ruled out PCOS and a few of the other usual suspects with an MRI scan at the time. But if you say the only way they know for sure is to go in surgically then who knows. All i know is my periods on the first few days have been so painful in the past. They did at around the age of 23-25 give me morphine for them. Luckily now i am a few years older the pain is by far less and controlled by Tramadol. Really my periods effect my POTs more than the crippling pain now a days. It wouldn't surprise me though if i did have Endometrosis. My god 8 surgery's to your abdominal area! How have you managed to stay so strong. I really think its fantastic how you appear very strong with all this. i know just becuase we may look like we are coping on the outside, inside can be a different story.But your advice seems to be so priceless on here.

Yes the 23 and me kit has been ordered so in a few weeks i will get some answers! Thanks for the heads up with trying to understand what comes back on it, i struggle on here at times so it will be very interesting to see how i go!! Pulling my hair out i should think!! I hate it when i read things and cant quite understand it!!!

I will follow your advice on it though. Will be fascinated to see what come back. Did you do your ancestry kit on there

Quick question for you, have you ever trialed Lyrica?

You sticking with the Clonidine still?

[issie]

Glad some of the things I say helps I think with each thing we go through in life - it will either make you stronger or break you. I guess, I'm a survivor.

I did try Lyrica a long time ago - it wasn't for me. As for clondidine - I've been off it for a few days - seeing if the edema gets better. So far, it hasn't. Wanted to see if the med was contributing to the edema - it doesn't appear to be doing that. I have found being off it that I'm having more orthostatic dropping issues. The clondidine seemed to level me out more. I was only on 1/4 of a pill two times a day - but, that was enough for my body. I will try to stay off if a few more days and see what my bp does and whether or not the edema gets better. But, tonight - I told my hubby, I think I'm better on it. So, we will see. Did you ever try it - can't remember - it's late and I'm tired tonight. So having the brain fog moments. Ha!Ha! Don't you just hate those?

Issie

[RichGotsPots]

I would try an allergist for the singulair. Also I have found this new thing called Platelet activating factors (PAF), very similar to mast cell issues.. wiki it, there is an antihistamine they list on there to try. I dont know if its over the counter yet..