kclynn Posted July 13, 2011 Report Share Posted July 13, 2011 My son missed his Florinef yesterday. He has been doing really good, quite active and pushing himself a bit. Today I couldn't get him up and now that he is up he is really lethargic, but I did make sure he took his florinef on time about 9 AM today and I was wondering how much effect missing that 1 dose could have or if it us just the "normal" ups and downs of POTS. Quote Link to comment Share on other sites More sharing options...
redoctober Posted July 13, 2011 Report Share Posted July 13, 2011 I suppose it depends upon the dose somewhat...Florinef has a pretty long half-life...so he'll still have some floating around even if he misses a dose. But, Florinef isn't something you can just stop out of the blue at higher doses, so I suspect that his body wasn't ready to compensate for the reduced serum levels. Quote Link to comment Share on other sites More sharing options...
kclynn Posted July 13, 2011 Author Report Share Posted July 13, 2011 I know it has to be tapered. He takes .1 so I think that is not a real high dose? Quote Link to comment Share on other sites More sharing options...
redoctober Posted July 13, 2011 Report Share Posted July 13, 2011 I wouldn't think so. When I started Florinef...I did so on too high of a dose (headaches)...and it took a few days of skipping doses to feel better, due to the long half-life. So, I doubt that skipping a single day is causing much of a problem for him. Just my experience. Quote Link to comment Share on other sites More sharing options...
Bears Mommy Posted July 13, 2011 Report Share Posted July 13, 2011 I had huge issues when I skipped a dose. It's why I quit taking it, but it took me over a month to taper off of. I might be wrong but from what I understand Florinef is a corticosteroid, specifically aldosterone. Aldosterone is a hormone that is made by your body. What happens when you take Florinef is that you body recognizes that there is enough aldosterone already and decreases it's production. Therefore if you miss a dose you don't have enough aldosterone in you body and your symptoms will increase. I missed a dose and got very sick; shaking, vomiting, weak, exhausted, etc - as soon as I took the missed dose I felt better. So yes, i think one missed dose can be detrimental. Quote Link to comment Share on other sites More sharing options...
Yolaclover Posted July 13, 2011 Report Share Posted July 13, 2011 I can miss one dose and feel ok Quote Link to comment Share on other sites More sharing options...
kclynn Posted July 13, 2011 Author Report Share Posted July 13, 2011 yeah, I suspect it has more to do with exceeding his available energy level, increased temps, and pots ups and downs that happen no matter what you do Quote Link to comment Share on other sites More sharing options...
autumn Posted July 14, 2011 Report Share Posted July 14, 2011 I'm OK during the day of the missed dose, but I'm *guaranteed* to have a hard time the next day, even if I take it. Quote Link to comment Share on other sites More sharing options...
kclynn Posted July 14, 2011 Author Report Share Posted July 14, 2011 Thanks for all the replies. Autumn - That is how Everything is for him which I think makes it even harder for a teen to "pace" themselves. Most teens want to go flat out, sleep late, do over again. Quote Link to comment Share on other sites More sharing options...
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