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POTS: An overview


An overview of Postural Orthostatic Tachycardia Syndrome

Standing up is something most of us take for granted; we've been doing it since childhood. Our bodies automatically adjust to the pull of gravity by increasing vascular tone, heart rate, and cardiac output. Blood vessels contract, heart rates increase and our systolic blood pressure remains the same or decreases slightly while diastolic pressure increases slightly (Brunner & Suddarth, 2000, p. 546). Our bodies operate in perfect homeostasis and we stand up with little effort. 

However, the simple act of standing up can be a challenge for some people. There are disorders that affect the body's ability to appropriately adjust to the pull of gravity. When the body cannot effectively adjust to upright posture, a person is said to have orthostatic intolerance. Postural orthostatic tachycardia syndrome (POTS) is a disorder characterized by orthostatic intolerance.  POTS is a disorder that is a part of the dysautonomia family of disorders.

The criteria for diagnosis of POTS is: (1) a sustained increase in HR of at least 30 bpm within 10 minutes of standing (often with an absolute upright HR  120bpm); (2) in the absence of sustained orthostatic hypotension (drop in BP > 20/10mm Hg); (3) with symptoms of orthostatic intolerance for at least 6 months. In patients < 19 years of age, there is a higher HR threshold for POTS (increment  ≥40 bpm or absolute uprights HR  ≥ 120 bpm) due to physiological orthostatic tachycardia in adolescents and children (Singer et al., 2012)  (Arnold, Ng, Raj, 2018)

While the hallmark of POTS is an excessive heart rate increment upon standing, patients often exhibit numerous symptoms of autonomic nervous system dysregulation, and research by the Mayo Clinic suggests POTS is a limited autonomic neuropathy (Thieben, Sandroni, Sletten, Benrud-Larson, Fealey, Vernino, Lennon, Shen & Low, 2007). Many POTS symptoms seem to be caused by an imbalance of the Autonomic Nervous System's  (ANS) control over blood flow. It is the autonomic nervous system (ANS) that regulates the needed adjustments in vascular tone, heart rate and blood pressure upon standing. Some of the messages coming from the autonomic nervous system tell the blood vessels to relax or tighten. In people with POTS, the system seems to be out of balance and blood is not going to the right place at the right time to do what the body needs (Fischer, 2007).

The autonomic nervous system is responsible for regulating a multitude of organs and functions throughout the body. Some of these functions include temperature, respiration, pupil dilation and constriction, salivation and the digestive tract. A patient experiencing ANS dysregulation may experience abnormalities in the many organs and functions the ANS regulates. For example, around one third to one-half of POTS patients have digestive troubles (Fischer, 2007). The problem is that blood flow is not matching the need, so blood is not going to the right part of the intestinal system when it needs to. As a result, these people have trouble with nausea. For a smaller percentage of patients, the trouble is that there is too much blood in parts of the intestines. The body is attempting to digest food when there is no food to digest. This leads to cramping and colicky-like pains (Fischer, 2007).

Patients commonly suffer from cognitive dysfunction, sleep disturbances and exercise intolerance.  The symptoms can be exacerbated by numerous factors including dehydration, heat exposure, prolonged recumbency (resting, reclining), alcohol, menstruation, and acute exercise. Syncope (fainting) is not a predominant feature of POTS (only ~20–30% actually pass out, and this is usually thought to be due to vasovagal syncope) (Shen et al., 2017); however, many patients experience frequent pre-syncopal episodes that impair functional capacity. (Arnold, Ng, Raj, 2018)

POTS can be categorized as primary, meaning it is idiopathic and not associated with other diseases, or secondary, meaning it is associated with a known disease or disorder (Grubb, Kanjwal & Kosinski, 2006). Common comorbidities include chronic fatigue syndrome, hypermobility type of Ehlers-Danlos syndrome, migraine, bowel irregularities, autoimmune disorders, and fibromyalgia(Garland et al., 2015).

POTS is described as a clinical syndrome consisting of multiple heterogeneous disorders (disorders with diverse character). Some have taken to labeling "POTS Subtypes", with article published alluding to hyperadrenergic POTS ("Hyper POTS"), neuropathic POTS ("Neuro POTS"), or hypovolemic POTS.  It is important to note that these subtypes do not all have standard definitions therefore there is a non-exclusivity of names with patients often having overlapping clinical features and symptoms that involve more than one subtype.  Also, these subtypes do not have universally accepted definitions, so the labels can be misleading.  "While one doctor may use the term "Hyper POTS" to refer to a specific set of findings, another doctor might think that it refers to a different set of findings.  In theory, this could harm a patient's care.  In our experience, these "subtype" labels are not clinically helpful."  (Arnold, Ng, Raj 2018)


People generally develop POTS after becoming sick with a virus, giving birth, or being exposed to great bodily stressors (i.e. surgery, trauma or chemotherapy). Some people have had POTS their entire lives. Teenagers sometimes develop the disorder during the years of rapid growth, and 75-80% of them can look forward to being asymptomatic when they reach adulthood (Grubb, Kanjwal & Kosinski, 2006).

The symptoms of POTS are life-altering and debilitating at times. POTS patients use about three times more energy to stand than a healthy person (Grubb, 2002). It is as if these patients are running in place all the time. Activities such as housework, bathing, and even meals can exacerbate symptoms (Grubb, Kanjwal & Kosinski, 2006). Research shows that POTS patients' quality of life is similar to those with congestive heart failure and chronic obstructive pulmonary disease (Benrud-Larson, Dewar, Sandroni, Rummans, Haythornthwaite & Low, 2002) Twenty-five percent of people with POTS are disabled and unable to work (Goldstein, Robertson, Esler, Straus, & Eisenhofer, 2002). Most patients will have to make some lifestyle adjustments to cope with this disorder.

It was once estimated that nearly 500,000 Americans had POTS, which made standing up a challenge (Robertson, 1999). However, with research advances and growing physician education, the number of people found to have POTS symptoms is steadily rising. It is now estimated that one out of every hundred teens has POTS (Fischer, 2007).

The minimal requirements to detect POTS on initial evaluation are a detailed medical history, physical examination with orthostatic vitals and a resting 12-lead ECG (Sheldon et al, 2015)  The medical history should document medications, other medical conditions including personal and family history of cardiac disease, joint hypermobility, autoimmunity or neurological disorders, and the nature of tachycardia including potential triggers, frequency, time of day, association with pre-syncopal or syncopal episodes, symptoms, and impact on daily activities.  (Arnold, Ng, Raj 2018)

POTS has a strong female predominance (4–5:1), and primarily affects women of childbearing age. Most patients present with POTS between 13 and 50 years of age, with a family history of orthostatic intolerance reported in approximately 13% of patients (Thieben et al., 2007).The onset can be sudden or gradual. The quantity and severity of symptoms vary from day to day.

There are treatments for POTS symptoms which can be tailored to each individual patient, especially if an underlying cause is discovered. Researchers are attempting to identify and treat the mechanisms and causes of POTS. Studies show that most patients will eventually be able to stand up with fewer symptoms (Low, 2000). Most people with POTS can look forward to experiencing improvement with proper treatment.

For more information on POTS, please view our other POTS links and resources.



1.  Amy C. Arnold, Jessica Ng, Satish Raj

               Postural tachycardia syndrome: Diagnosis, Physiology and Prognosis    
               Autonomic Neuroscience, Vol 215 December 2018

 2. Benrud-Larson, L. M., Dewar, M. S., Sandroni, P., Rummans, T. A., 

  Haythornthwaite, J. A., &  Low, P. A. (2002, June). Quality of life in 
  patients with postural tachycardia syndrome. Mayo Clinic Proceedings,  
  77, 531-537. 
  Full text: http://www.mayoclinicproceedings.com/inside.asp?
3. Brunner, L. S. & Suddarth, D. S. (2000). Assessment of cardiovascular
  function. In S. C. Smeltzer & B. G. Bare (Eds.), Brunner and Suddarth's
  textbook medical-surgical nursing (pp. 532-563). Philadelphia, PA:
  Lippincott Williams and Wilkins.
4. Fischer, P. (2007). Postural orthostatic tachycardia syndrome. Mayo Clinic
  Podcast. http://www.podcastingnews.com/details/www.
5. Goldstein, D., Robertson, D., Esler, M., Straus, S., & Eisenhofer, G. (2002).
  Dysautonomias: clinical disorders of the autonomic nervous System.
  Ann Intern Med., 137, 753–763. Full Text
6. Grubb, B. P. (2000, July). Orthostatic intolerance. National Dysautonomia 
  Research Foundation Patient Conference. Minneapolis, Minnesota.
7. Grubb, B. P. (2002, October). The heterogeneity of symptoms related to 
  dysautonomia. Symposium conducted at the meeting of the
  National Dysautonomia Research Foundation Northwest Ohio
  Support Group. Toledo, Ohio.
8. Grubb B. P., Kanjwal, Y., & Kosinski, D. J. (2006). The postural
  tachycardia syndrome: A concise guide to diagnosis and management.
  J Cardiovasc Electrophysiol., 17, 108-112.
9. Grubb, B. P., & McMann, M. C. (2001). The Fainting Phenomenon: 
  Understanding why people faint and what can be done about it.   
  New York: Futura Publishing Company.
10. Low, P. A. (2000, July). Orthostatic intolerance. National Dysautonomia 
  Research Foundation Patient Conference. Minneapolis, Minnesota.
11. Robertson, D. (1999). The epidemic of orthostatic tachycardia and orthostatic
  intolerance. The American  Journal of the  Medical Sciences, 317, 75-
12. Thieben, M. J., Sandroni, P., Sletten, D. N., Benrud-Larson, L. M.,
  Fealey, R. D., Vernino, S., Lennon, V. A., Shen, W. K.,  &
  Low, P. A., (2007).  Postural orthostatic tachycardia syndrome: the
  Mayo Clinic experience. Mayo Clin. Proc. 82, (3), 308-313.
  Full Text

Edited by edriscoll

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