janiedelite Posted February 2, 2010 Report Share Posted February 2, 2010 I started domperidone 4 days ago. It feels more and more difficult to be upright. I'm taking 10mg three times a day, pretty low dose. I'm going to avoid taking it today and see if I feel any better. I do appreciate how it helps with my nausea and upper GI burning. But I have to function. Although, this could easily just be a flare of some kind. So I don't want to rule out this medication right away. I've read all the domperidone posts here, but hadn't come across anyone dealing with increased fatigue as a result of taking it. Please share your thoughts............yawn. Quote Link to comment Share on other sites More sharing options...
brownsea Posted February 2, 2010 Report Share Posted February 2, 2010 hi ive been on domperidone for a while now, since last may. it did the trick with the nausea not sure about increased fatigue though. as i felt that before and after i took them.before i took dom, i tried a few other anti-nausea tablets which didnt work.emma.xxx Quote Link to comment Share on other sites More sharing options...
janiedelite Posted February 2, 2010 Author Report Share Posted February 2, 2010 Thanks, Emma. Yes, I really hope that the increased fatigue is just a fluke. I took my BP this morning and it was 80/50 pulse 97 after standing a few minutes. I was feeling quite presyncopal. My BP is NEVER low, instead goes up too high on standing usually. But since I've been on carvedilol, it's just stayed within normal ranges on standing.So I went outside into the cool air, walked a bit, and now my BP is 100's/70's and I feel better, but still more sluggish than normal. Still, I'm going to hold off on taking the domperidone today and see if I feel any better. I'm wondering how long it takes to get it out of your system. The half-life is 7 hours, so I'd think it would be worn off by now (took last dose 15 hours ago). Quote Link to comment Share on other sites More sharing options...
Lenna Posted February 2, 2010 Report Share Posted February 2, 2010 It was interesting timing to see your post. My son has been on Domperidone for over a year and it helps so much with his nausea. But I refilled his prescription yesterday and was noticing that the compounding pharmacy wrote the words "may cause dizziness" in larger letters than they had previously.It got me thinking. My son takes Domperidone as soon as he wakes up, and his morning dizziness has increased lately to the point where it's interfering with getting to school. So I was just thinking about trying to delay his first dose of Domperidone until later in the day to see if it decreases the morning dizziness. Now, after reading your post, I wonder if it might also increase his morning fatigue. On the other hand, his second dose of Domperidone is in the late afternoon, and I haven't noticed him getting more dizzy or fatigued after that dose. But it's worth experimenting, I guess. Quote Link to comment Share on other sites More sharing options...
janiedelite Posted February 2, 2010 Author Report Share Posted February 2, 2010 I spoke with the GI doc who prescribed the domperidone and she said to stop for a week and see how I feel. I'll do this, but I hope I can resume this med as it so helps the nausea! Quote Link to comment Share on other sites More sharing options...
brownsea Posted February 2, 2010 Report Share Posted February 2, 2010 good luck thankful.its worth giving it a go. xxx Quote Link to comment Share on other sites More sharing options...
Janey Posted February 2, 2010 Report Share Posted February 2, 2010 I started taking domperidone a week ago and haven't been able to get up in the morning til midday... even if I go to bed early the night before. Do you think they're connected? Quote Link to comment Share on other sites More sharing options...
janiedelite Posted February 3, 2010 Author Report Share Posted February 3, 2010 I started taking domperidone a week ago and haven't been able to get up in the morning til midday... even if I go to bed early the night before. Do you think they're connected?Janey, have you checked your orthostatic BP/pulse? Have you noticed any worsening orthostatic hypotension?I've searched the internet for common side effects and they only list orthostatic hypotension as the side effect of an overdose. In fact, I even found one study that used florinef in conjuction with domperidone in order to raise BP with parkinson's patients with OH. And one study of diabetics with OH showed that regular domperidone raised their standing BP also.The fatigue seems to have lifted for now. My BP seems to have improved also. I'll give it a few more days and see if it returns. I must just be wierd. Quote Link to comment Share on other sites More sharing options...
megan2 Posted February 3, 2010 Report Share Posted February 3, 2010 Domperidone can cause QT interval prolongation, which can cause dizziness. It can also cause sudden death to torsade de pointes if your QT interval is long enough. I would have an EKG done while on the drug to make sure your QT interval is within acceptable limits. For most people this is not a problem, but if you're having any cardio side effects...please get an EKG! Domperidone helped me a lot, so I know it's a great drug and can be worth it, but for me because of the cardiac side effects I could not continue taking it. My GI didn't really think the QT issue was something to be concerned about, but the other GI in the office who was substituting for him one day got angry that they weren't running EKGs and my cardio made me stop it. I was also having severe chest pain though.It also made me sleepy, but that was more a nuisance. Quote Link to comment Share on other sites More sharing options...
janiedelite Posted February 3, 2010 Author Report Share Posted February 3, 2010 Domperidone can cause QT interval prolongation, which can cause dizziness. It can also cause sudden death to torsade de pointes if your QT interval is long enough. I would have an EKG done while on the drug to make sure your QT interval is within acceptable limits. For most people this is not a problem, but if you're having any cardio side effects...please get an EKG! Domperidone helped me a lot, so I know it's a great drug and can be worth it, but for me because of the cardiac side effects I could not continue taking it. My GI didn't really think the QT issue was something to be concerned about, but the other GI in the office who was substituting for him one day got angry that they weren't running EKGs and my cardio made me stop it. I was also having severe chest pain though.It also made me sleepy, but that was more a nuisance.No chest pain or dizziness. Just super sluggish with low BP. However, I have to say since I've stopped the medication (been off it for 36 hrs how) I feel completely back to my "normal." BP is back up too. Domperidone is not the med for me, I guess. Quote Link to comment Share on other sites More sharing options...
erik Posted February 8, 2010 Report Share Posted February 8, 2010 If you like bubbles and can afford it I guess Dom Peridone is not a bad way to go. You must have good taste & insurance. My coverage tops out at Cold Duck, which doesn't impress the ladies much. I've had the least fatigue from Zima but I guess it was pulled from z market. Quote Link to comment Share on other sites More sharing options...
joy Posted February 9, 2010 Report Share Posted February 9, 2010 when I had GERD I was on high doses of prilosec, which helped my nausea in turnthey now sell it over the counter in lower dosages (i believe) Quote Link to comment Share on other sites More sharing options...
janiedelite Posted February 9, 2010 Author Report Share Posted February 9, 2010 Thanks, Joy. I'm already on protonix which is also a proton-pump inhibitor like prilosec. I'm just on the standard prescription dose, though. I will be calling my GI doc and letting her know that it was definitely the domperidone that caused that fatigue. I do have high-grade reflux, but I think the dysmotility just worsens it.We do have good health insurance, but I paid for the domperidone myself.Update: my GI doc is going to try erythromycin. Yay! Quote Link to comment Share on other sites More sharing options...
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