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  1. Here is the full abstract of the study http://hyper.ahajournals.org/content/51/2/412.full . Many of us are believed to have Mitochondrial Deficiencies and we are not sure if it is primary or secondary. But it could play a role in a lot our fatigue and other symptoms. I also have a theory that many of our symptoms are a result of what I call localized hypertension. Just like some of us have Orthostatic BP flucuations, I believe some other mechanism make our BP irregular in different parts of our bodies. And if one of us have a symptom that bothers us more it's because of the irregularity is localized to an area of the body that causes that type of symptom. This all ties into autonomic dysfunction. Even if one of has dysfunction because of a completely different illness than from another person, treating this local fluctuation might be a key, might, just a theory so far... Mitochondrial Dysfunction Mitochondrial Dysfunction in the Hypertensive Rat Brain Respiratory Complexes Exhibit Assembly Defects in Hypertension The central nervous system plays a critical role in the normal control of arterial blood pressure and in its elevation in virtually all forms of hypertension. Mitochondrial dysfunction has been increasingly associated with the development of hypertension. Perspectives The central nervous system plays a critical role in the normal control of arterial blood pressure and in its elevation in virtually all forms of hypertension. Our findings suggest that, in already-hypertensive SHRs, the brain respiratory complexes exhibit previously unknown assembly defects. These defects impair the function of the mitochondrial respiratory chain. This mitochondrial dysfunction localizes to the brain stem and is, therefore, likely to contribute to the development, as well as to pathophysiological complications, of hypertension. Interestingly, mitochondrial dysfunction in the central nervous system has been extensively investigated for several neurodegenerative diseases, including vascular dementia, Alzheimer’s, Huntington’s, and Parkinson’s disease.34–37 It is striking that the dysfunction that occurs in these diseases shares many molecular commonalities with that found in the current research in the context of hypertension. Future research should further explore the emerging link among hypertension, mitochondrial dysfunction, and neurodegeneration and the cause-effect relationships.
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