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Found 2 results

  1. A lady I know whose kids have MCAD and POTS compiled some really interesting research, would love opinions on this (sorry if its already been discussed, I searched the forum and didnt find much): "OK, I wonder if I may be on to something here. At the very least, I’m learning a lot. Please post your thoughts. We know that Nitric Oxide levels tend to be high in POTS patients, as seen here: Cutaneous constitutive nitric oxide synthase activation in postural tachycardia syndrome with splanchnic hyperemia. http://www.ncbi.nlm....pubmed/21642500 (Splanchnic hyperemia is blood pooling in the stomach) Flow-mediated vasodilation and endothelium function in children with postural orthostatic tachycardia syndrome. http://www.ncbi.nlm....pubmed/20643249 Nitric Oxide also is shown to be increased in patients with migraines: Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine. http://www.ncbi.nlm....pubmed/21359872 Nitric oxide supersensitivity: A possible molecular mechanism of migraine pain. http://psycnet.apa.o.../1994-14066-001 And in patients with CFS/ME: Kindling and Oxidative Stress as Contributors to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome http://www.ncbi.nlm....les/PMC3022475/ (This is an excellent and thorough article that points to oxidative stress as a factor in autonomic function.) As well as Multiple Chemical Sensitivity: Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder. http://www.ncbi.nlm....pubmed/12000033 In fact, Nitric Oxide’s role is multifaceted, and an excessive amount can lead to neuronal injury: Nitric oxide in health and disease of the nervous system. http://www.ncbi.nlm..../pubmed/9246670 Neurobiology of nitric oxide. http://www.ncbi.nlm..../pubmed/8978984 Including Mitochondrial dysfunction: Nitric oxide-induced mitochondrial dysfunction: implications for neurodegeneration. http://www.ncbi.nlm....pubmed/12543245 Nitric oxide, mitochondria and neurological disease http://www.sciencedi...005272898001686 So what causes high levels of Nitric Oxide? Histamine? Quite possibly: Nitric oxide: a regulatory mediator of mast cell reactivity http://journals.lww....st_cell.47.aspx Nitric oxide accounts for histamine-induced increases in macromolecular extravasation http://ajpheart.phys...6/6/H2369.short Nitric Oxide and Histamine Induce Neuronal Excitability by Blocking Background Currents in Neuron MCC of Aplysia http://jn.physiology.../2/656.abstract Nitric oxide production in human endothelial cells stimulated by histamine requires Ca2+ influx http://www.ncbi.nlm....pdf/9480877.pdf"
  2. Can anyone tell me why when i take benadryl it really helps me and calms my anxious, heart pounding fidgity feeling? I have had pots for 6 years also have eds, not sure if that is my cause or if there is another cause as well as mine started after a surgery. My pots for 4 years was where normal heart rate lying down and about 150s upon standing, have never fainted, always cold, headaches, lightheadedness. The last 2 years I have had excessive sweating, still cold hands and feet but flushing in my face and upper trunk, really high levels of norepinephrine, anxiety episodes (not really anxiety though). I don't know what type I have or what other problems disorders I may have. I was just dx in this last year trying to get in with Dr Goodman for more testing to try to find out, but since i don't understand a lot of the medical terms, does it seem like there is a mast cell problem possibly or what does it mean with norepinephrine and why would a anti histamine like benadryl help with my symptoms of pots? And is there something else that works better, I have heard of histamine nlockers but don't know much? I am not really being treated right now as they have tried a couple beta blocker and florinef and they have not worked?
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