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Found 6 results

  1. PR Newswire PHILADELPHIA, March 29, 2012 PHILADELPHIA, March 29, 2012 /PRNewswire/ -- Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, reaffirms its commitment to patients as set forth in its recent agreement with the Center for Drug Evaluation and Research (CDER) at the U.S. Food and Drug Administration (FDA) to conduct two additional clinical trials to verify and describe the clinical benefit of midodrine HCI. Midodrine HCl, approved in 1996 under Subpart H (an accelerated approval process) for the treatment of symptomatic orthostatic hypotension (SOH),
  2. Hello Everyone, After a really bad spell where I was fainting almost every time I stood up, I tried Midodrine again. 2.5 mg three times per day. After three weeks, I needed to push the dose to 5 mg, three times/day. I lost 10 pounds in 20 days, and unfortunately, I need to gain some weight, not lose anymore. Has anyone else had this problem? I cannot tolerate Florinef, and my doctor at Mayo has told me to cut back to 2.5 again over the weekend to see what happens. I don't want to lose the energy the drug gives me, but the side effects are tough...no appetite, digestion issues, headache, etc. A
  3. Whoa... No one told me anxiety was a side effect from midodrine... I thought this stuff wasnt supposed to be able to cross the blood brain barrier? First day i was getting migraine auras, second day jitteriness, third day more jitteriness. Took a break from it, felt better. Went back on, first day not bad and less dizzy, second day quesy and jittery again, third day WHOA!!! my mind was racing, I felt kind on edge in the extreme and even kinda emotional (which is usually not me at all). My wife came home from work, took one look at me and told me to get off it straight away. As soon as my last
  4. Started my midodrine trial yesterday with some interesting results. First hour it felt just 'odd' and 'slightly synthetic' - i still felt dizzy and actually felt kinda tired. Second hour it amped up but it wasnt what i was expecting. Instead of less dizziness I was just amped with energy. More energy than I knew what to do with. Walked the dogs three times, cleaned the front yard, talked to the neighbour and was more ingrossed in the conversation perhaps because I didnt feel like fainting constantly. Got no side effects but I did crash - but not until 9pm that night and it made me feel pretty
  5. The FDA has updated their docket on Midodrine "FDA/OC Letter to Parties from the Office of the Commissioner, dated January 23, 2012" http://www.regulations.gov/#!documentDetail;D=FDA-2007-N-0475-0037 click on the "view attachment" PDF icon to read it I don't have the congitive capacity right now to figure out what it means LOL.
  6. Hi everyone, Sorry if this is something that's been discussed, but I couldn't find it in any past threads. I've recently started midodrine and noticed that my systolic blood pressure has risen from the low range (used to be 80-90 and is now 90-120), but my diastolic blood pressure is still pretty low (anywhere from 40s-60s). I know that diastolic bp is the pressure when your heart is not beating, but what does that mean as far as POTS and symptoms go? I have to say, I've felt different, but not exactly better on midodrine so far--it's almost like I have more nervous energy sometimes, but I sti
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