I've recently been suffering with a so-called neurogenic bladder. (Several days ago I sent you a PM through this site.) Anyhow, some tips to try for the soreness: -Clean with mineral oil on a cotton ball which would also provide a little protetive barrier for the skin -Desitin (baby) cream - a thicker barrier to prevent chafing and promote healing -Launder underwear in Dreft or any other gentle baby detergent -Hypoallergenic, fragrance free sensitive baby wipes instead of tp -Be very careful of seams in underwear (location and thickness of them) and you may be more comfortable in skirts instead of pants for a while. Again, with pants be careful that the seams are not creating a large lump and subsequently, pressure where they overlap. -OTC feminine anasthetic cream with benzocaine for severe soreness, esp. if you need to sit. It might sting for a few minutes, but numbs you for a few hours. Vesicare prescribed by my rheumatologist helped me although the specialists I saw (urologist and 2 neurourologists) said it shouldn't work and would be contraindicated with some of my findings, yet they had nothing to offer. Dr. Grubb and I very briefly discussed this. When I asked about DDAVP as he recommends in his Syncope book, he mentioned recent use of Cialis for POTS/neurogenic bladder. He said many POTS patients have neurogenic bladder and overflow incontinence. I asked him for some info in medical literature or studies, but have yet to recieve any. I will pass along anything useful I come across. As an aside, Detrol LA made me worse - after 2 weeks I had to strain a lot although I still always had the urge to go. It took a while to find something that helped, so as long as the Vesicare works I'm sticking with it. Take care. LIT