Report Switching To Bisoprolol From Propranolol (Anyone Have Luck With Bisoprolol?) in Dysautonomia Discussion Posted July 5, 2012 Propranolol has been very helpful to me - it's helped lower my standing HR from 150-180 to about 80-100. So that's a big improvement for me in addition to reducing some overally jittery feelings I get from POTS.My allerigies are acting up and I am showing minor asthma symptoms from a lung test. Propranolol is the medicine (and Midodrine) that have allowed me to go back to work. It's not easy...and I struggle with fatigue and other issues...but I'm making it.This switch is huge to me. I was told the two Blockers are fairly similar and to start Bisoprolol at 5mg for a few days and if it's not enough, up it to 10mg. I was also told there would be an adjustment period (the first week worse, the first month overall adjusting).I'm only allowed one week off of work for medical leave to do this, so I'm hoping for the best.Any advice on switching Blockers and using Bisoprolol?