I didn't feel like Mayo answered my questions well enough. They basically said....here is your diagnosis...we don't know the best way to treat it...you just need to figure out a way to live with it...come back in 6 months! Hi Lisa, I'm new here too, although I've had POTS for years. that is so frusterating!!!! that happened to me when I went to Vanderbuilt. For me they looked at everything we had tried so far. ( I was part of the clinical trials for Midodrin, had tried beta blockers, atenolol, and every other med they could think of out there before going) And basically told me well there's nothing else to try so go home and live with it.. It can be so depressing. But don't give up, I've been amazed at what I've been reading here and what all can be tried and adjusted to help. I'll keep you in my thoughts.