I have chronic progressive dysautonomia, EDS and MCAS which I have learned are great friends. Anecdotally I found that a 50 mg tramadol will get me through an entire work day. Not bc it helps with pain, although it does mask my flu like aches, but bc it somehow helps my mood, energy level and ability to stay upright and even stay warm. It’s crazy and I was just searching to find if anyone else feels that way. I am only working every other day and only take it if I work. Then I rest a day. I would only pull 3 hours off at my job without it