I have been on coreg CR for about 7 years for my POTS. Lately, for about the past 3 to 4 months I have been experiencing a major amount of PVC'S and lots of anxiety to go along with it. My cardiologist tried increasing my coreg but I could not tolerate it, it knocked me on my butt. Now he is switching me to Metoprolol to see if it helps any better. My blood pressure is not really an issue, just the heart rate and the PVC'S. Anyone been on metoprolol for this ? Any advice?