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Posts posted by Stark

  1. On 12/29/2019 at 8:30 AM, p8d said:

    I was extremely ill, 84 pounds, on TPN, could only stand for a couple of minutes and housebound. 

    This is basically my current situation. Did you manage to get off of TPN? You've convinced me that I really need to start doing SOME kind of limited exercise

  2. Researchers at the University of Oklahoma have published a study on the first animal model of POTS, an essential step in confirming whether or not a condition is an autoimmune disease. Additionally, they report that antibodies similar to those found in POTS patients cause tachycardia in rabbits. Perhaps even more importantly, they have identified a potential new drug that inhibits the effect of the antibodies.

    This study demonstrates for the first time a role of adrenergic autoimmunity in the pathophysiology of POTS in two related animal models.

    The study also demonstrates that the effects of adrenergic autoantibodies are largely reversed using a compound that blocks the autoantibodies, which was developed by the University of Oklahoma researchers.

    The JAHA research article: www.ahajournals.org/doi/10.1161/JAHA.119.013006

    The JAHA editorial that emphasizes the importance of the findings: www.ahajournals.org/doi/10.1161/JAHA.119.014084

  3. Does anyone have any theories for why bradycardia occurs in POTS? When I came down with POTS last fall, my resting heart rate was consistently in the 70s (and of course increasing when I stood up). However, it has slowly decreased over the past 7 months until it is now in the mid 40s. Meanwhile, I have only been getting MORE deconditioned, so it's not a case of me getting into better shape. I'll note that I don't experience any symptoms from a low heart rate. 

    I've seen others have this issue as well, does anyone have any theories? I'm thinking it might have something to do with acetylcholine or the receptors? 

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