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Stark

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Posts posted by Stark

  1. On 12/29/2019 at 8:30 AM, p8d said:

    I was extremely ill, 84 pounds, on TPN, could only stand for a couple of minutes and housebound. 

    This is basically my current situation. Did you manage to get off of TPN? You've convinced me that I really need to start doing SOME kind of limited exercise

  2. Researchers at the University of Oklahoma have published a study on the first animal model of POTS, an essential step in confirming whether or not a condition is an autoimmune disease. Additionally, they report that antibodies similar to those found in POTS patients cause tachycardia in rabbits. Perhaps even more importantly, they have identified a potential new drug that inhibits the effect of the antibodies.

    This study demonstrates for the first time a role of adrenergic autoimmunity in the pathophysiology of POTS in two related animal models.

    The study also demonstrates that the effects of adrenergic autoantibodies are largely reversed using a compound that blocks the autoantibodies, which was developed by the University of Oklahoma researchers.

    The JAHA research article: www.ahajournals.org/doi/10.1161/JAHA.119.013006

    The JAHA editorial that emphasizes the importance of the findings: www.ahajournals.org/doi/10.1161/JAHA.119.014084

  3. I sort of fall into this camp. My resting heart rate is in the 40s (sometime upper 30s when lying down for extended periods). It rises to the 80s or 90s when I stand, which is more than enough for a POTS diagnosis, but isn't technically a considered tachycardia since it is usually sub 100 bpm

  4. No, I was extremely athletic (gym 6 times per week) before the onset of symptoms. My resting heart rate was around 60. I have now not done any exercise in months and my resting heart rate is now 15 points lower (although at the start of my condition it was much higher at first, probably around 70). Weird stuff 

  5. Does anyone have any theories for why bradycardia occurs in POTS? When I came down with POTS last fall, my resting heart rate was consistently in the 70s (and of course increasing when I stood up). However, it has slowly decreased over the past 7 months until it is now in the mid 40s. Meanwhile, I have only been getting MORE deconditioned, so it's not a case of me getting into better shape. I'll note that I don't experience any symptoms from a low heart rate. 

    I've seen others have this issue as well, does anyone have any theories? I'm thinking it might have something to do with acetylcholine or the receptors? 

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